A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. [1] Protein kinases are enzymes that phosphorylate (add a phosphate , or PO …

2025年1月31日 · There are 80 FDA-approved small molecule protein kinase inhibitors as of 2023. This enzyme family is one of the most important drug targets in the 21st century.

Blocking certain protein kinases may help keep cancer cells from growing. Some protein kinase inhibitors, such as imatinib, vemurafenib, and gefitinib, are used to treat cancer. Search NCI's …

2018年2月19日 · Since the development of the first protein kinase inhibitor, in the early 1980s, 37 kinase inhibitors have received FDA approval for treatment of malignancies such as breast …

An antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or …

2023年7月20日 · A protein kinase inhibitor is a type of enzyme inhibitor that can block the action of protein kinases.

This research topic delves into a comprehensive exploration of protein kinases, their metabolic pathways, and associated inhibitors. We also warmly welcome recent advances in the use of …

2021年7月22日 · In this study, we have addressed the role of protein kinase in human cells and the effects of protein kinase inhibitors in the treatment of various diseases and disorders. …

2024年11月10日 · There are 82 small molecule protein kinase inhibitors and 4 antibody kinase inhibitors FDA-approved for treating cancers and other diseases (see Tables 1.1 and 1.2). …

In 2023, a comprehensive review highlighted the properties of 72 FDA-approved small molecule protein kinase inhibitors, noting that many of these drugs target specific kinases involved in...