Protein A is a 42 kDa surface protein originally found in the cell wall of the bacteria Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR.

2024年11月17日 · To comprehend the full scope of proteins, it is crucial to understand various properties, including the basic biological molecule, peptides, polypeptide chains, amino acids, protein structures, and the processes of protein denaturation.

2019年2月26日 · Protein A is a 42KDa cell surface protein which is found on the cell walls of 90% of Staphylococcus aureus bacterial strains. It is encoded for by the polymorphic X-region of the SpA gene, and...

Protein A is a multifunctional CWA protein that is both covalently anchored to peptidoglycan by sortase A and released into the extracellular milieu [50,75,76]. Protein A has five domains which recognize several different ligands, including tumour necrosis factor receptor-1 (TNFR-1).

2020年11月15日 · Protein A, a major cell wall component of Staphylococcus aureus, is one of the first immunoglobulin-binding proteins that is discovered about 80 years ago. However, a great deal of development in both purification methods and …

2019年12月31日 · Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.

2020年11月15日 · Protein A, a major cell wall component of Staphylococcus aureus, is one of the first immunoglobulin-binding proteins that is discovered about 80 years ago. However, a great deal of development in both purification methods and …

Protein A is a 42-kDa protein found in the cell wall of Staphylococcus aureus that has a high affinity for the Fc region of immunoglobulins from various species. It is commonly used in immunoassays to detect and quantify antigens immobilized on a solid support. AI generated definition based on: Immunoassay, 1996

Protein A (SpA), a surface molecule of S. aureus, binds the Fcγ domain of immunoglobulin (Ig) and cross-links the Fab domain of V H 3-type B cell receptors (IgM). Here we generated S. aureus spa variants harboring amino acid substitutions at four key residues in each of the five Ig-binding domains of SpA.

2017年12月13日 · Learn about proteins, a large class of biological molecules. Discover their structure and function and get protein examples.