2024年12月25日 · PRODH (Proline Dehydrogenase 1) is a Protein Coding gene. Diseases associated with PRODH include Hyperprolinemia, Type I and Schizophrenia 4 . Among its related pathways are superpathway of L-citrulline metabolism and Proline catabolism .

The PRODH gene provides instructions for producing the enzyme proline dehydrogenase (also known as proline oxidase), which is found primarily in the brain, lung, and muscle. Within cells of these organs, this enzyme functions in energy-producing structures called mitochondria.

Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence. Prognostic and immunomodulatory roles of schizophrenia-associated genes HTR2A, COMT, and PRODH in pan-cancer analysis and glioma survival prediction model.

Here, we investigated whether proline dehydrogenase (PRODH), a mitochondrial flavoenzyme catalyzing the key step in proline degradation, played a role in NSCLC tumorigenesis.

The PRODH gene provides instructions for producing the enzyme proline dehydrogenase (also known as proline oxidase), which is found primarily in the brain, lung, and muscle.

Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane flavoprotein linked to electron transport for anaplerotic glutamate and ATP production, most critical for cancer cell survival under microenvironmental stress conditions.

Proline dehydrogenase (ProDH) catalyses the first and rate‐limiting step in the transformation of proline (Pro) into glutamic acid (Glu) that takes place at mitochondria. This enzyme oxidizes Pro into delta‐1‐pyrroline‐5‐carboxylate (P5C) using FAD as cofactor.

To test the functional consequences of the polymorphic and rare variant PRODH alleles, we expressed all 16 known PRODH missense mutations individually and, in some instances, as haplotypes with multiple mutations in cis.

2021年7月21日 · Proline dehydrogenase (PRODH) enzyme, which catalyzes the first step of proline catabolism, has diverse functional roles in regulating many pathophysiological processes, including apoptosis, autophagy, cell senescence, and cancer metastasis.

2024年12月21日 · Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. Natarajan SK, Zhu W, Liang X, Zhang L, Demers AJ, Zimmerman MC, Simpson MA, Becker DFNatarajan SK, et al. Free …