Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene. [ 5 ] [ 6 ] Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine ...

Dec 25, 2024 · PRMT6 (Protein Arginine Methyltransferase 6) is a Protein Coding gene. Diseases associated with PRMT6 include Male Infertility and Azoospermia. Among its related pathways are Gene expression (Transcription) and Chromatin organization.

Dec 5, 2024 · Protein Arginine Methyltransferase 6 (PRMT6) is a Type I PRMT enzyme that plays a role in the epigenetic regulation of gene expression by methylating histone and non-histone proteins. It is also involved in various cellular processes, including alternative splicing, DNA repair, and cell signaling.

Oct 9, 2023 · In this study, we established that PRMT6 exerted a positive regulatory influence on breast cancer metastasis through both in vivo and in vitro experiments. Mechanistically, we innovatively...

May 18, 2021 · PRMT6 demonstrates oncogenic activity by inducing the addition of the epigenetic repressive H3R2me2a mark on tumor suppressor genes, such as p21 WAF1 and p16 INK4A, which facilitates cell ...

Huang et al. show that PRMT6 methylates RCC1 at arginine 214, which is required for RCC1 association with chromatin and activation of RAN. CK2 phosphorylates and stabilizes PRMT6 through deubiquitylation. Inhibition of PRMT6 reduces tumorigenicity of glioblastoma (GBM) cells and improves the impact of radiotherapy on GBM growth in mice.

Jan 1, 2023 · Here we report that protein arginine methyltransferase 6 (PRMT6) is highly expressed in lung cancer and is required for cell metabolism, tumorigenicity, and cisplatin response of lung cancer.

Aug 18, 2024 · 研究发现提示prmt6/stat1/acsl1轴是预防和治疗dn的一个新的治疗靶点。 研究旨在探讨蛋白精氨酸甲基转移酶6 (prmt6)在dn中调节铁死亡的确切作用。研究使用了由野生型和prmt6敲除(prmt6 −/−)小鼠组成的小鼠dn模型。转录组学和脂质组学分析，以及各种分子生物学方 …

Feb 8, 2025 · Data suggest that histone-arginine N-methyltransferase PRMT6 (PRMT6) plays an oncogenic role in prostate cancer (PCa) and predicts for more clinically aggressive disease, constituting a potential target for patients with Prostate cancer (CRPC).

Here we report that protein arginine methyltransferase 6 (PRMT6) is highly expressed in lung cancer and is required for cell metabolism, tumorigenicity, and cisplatin response of lung cancer. PRMT6 regulated the oxidative pentose phosphate pathway (PPP) flux and glycolysis pathway in human lung cancer by increasing the activity of 6-phospho ...