Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene. [5][6] This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce …

2024年12月25日 · PRDX1 (Peroxiredoxin 1) is a Protein Coding gene. Diseases associated with PRDX1 include Methylmalonic Aciduria And Homocystinuria, Cblc Type and Methylmalonic …

Variants (also known as mutations) in the PRDX1 gene are involved in methylmalonic acidemia with homocystinuria, epi-cblC type (shortened to epi-cblC), which is one form of a disorder that …

Peroxiredoxins (PRDXs), a ubiquitous family of redox‐regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant …

In this paper, we review the structure, effector functions of PRDX1, its role in cancer and the pivotal role of ROS in anticancer treatment.

Peroxiredoxins (Prxs, EC 1.11.1.15; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine -induced peroxide levels and thereby mediate …

Prdx1 deficiency increases macrophage foam cells in atherosclerotic plaques. To elucidate whether the impaired lipophagic flux caused by oxidative stress in Prdx1-deficient …

Prdx1 prevents Akt-driven tumorigenesis through protecting PTEN lipid phosphatase activity from oxidation-induced inactivation. (A) Prdx1 regulates PTEN phosphatase activity during …

2024年1月1日 · PRDX1 plays a dual role as both peroxidase and molecular chaperone. PRDX1 can be both tumour promotor and suppressor. PRDX1 inhibitors has proved antitumour …

2024年9月19日 · Membrane Bound Peroxiredoxin-1 Serves as a Biomarker for In Vivo Detection of Sessile Serrated Adenomas. PRDX1 gene-related epi-cblC disease is a common type of …

2017年8月21日 · Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H 2 O 2 and alkyl hydroperoxide and plays …

2013年1月21日 · Recent studies suggest that Peroxiredoxin 1 (Prdx1), in addition to its known H 2 O 2 -scavenging function, mediates cell signaling through redox-specific protein–protein …

2021年8月13日 · Peroxiredoxin 1 (PRDX1) belongs to an abundant family of peroxidases whose role in cancer is still unresolved. While mouse knockout studies demonstrate a tumour …

2024年3月1日 · One of the identified proteins is PRDX1, also known as peroxiredoxin 1, which is a 23-kDa redox protein found in macrophages that is generated by stress and exhibits many …

2022年11月3日 · PRDX1 is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular …

2016年9月21日 · PRDX1 is proven to be a versatile molecule regulating cell growth, differentiation and apoptosis. Recent studies have found that PRDX1 and/or PRDX1-regulated ROS …

This study reveals that PRDX1 is crucial to regulating lipophagic flux and maintaining macrophage cholesterol homeostasis against oxidative stress. We suggest that PRDX1-dependent control …

PRDX1, which belongs to the PRDX family, is composed of thiol-specific antioxidant enzymes that reduce H 2 O 2 and peroxynitrite [40, 41] and is associated with mitigation of oxidative …

2016年7月8日 · Our findings suggest that the interaction of PRDX1 with APE1 represents a novel anti-inflammatory function of PRDX1, whereby the association safeguards APE1 from …

2024年12月17日 · PRDX1 plays a crucial role in protecting HepG2 HCC cells from oxidative stress, with decreased levels correlating with heightened apoptosis, revealing its pivotal …