
Peroxiredoxin 1 - Wikipedia
Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene. [5][6] This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. [7] .
PRDX1 Gene - GeneCards | PRDX1 Protein | PRDX1 Antibody
2024年12月25日 · PRDX1 (Peroxiredoxin 1) is a Protein Coding gene. Diseases associated with PRDX1 include Methylmalonic Aciduria And Homocystinuria, Cblc Type and Methylmalonic Acidemia. Among its related pathways are Nuclear events mediated by NFE2L2 and Gene expression (Transcription).
PRDX1 gene - MedlinePlus
Variants (also known as mutations) in the PRDX1 gene are involved in methylmalonic acidemia with homocystinuria, epi-cblC type (shortened to epi-cblC), which is one form of a disorder that causes developmental delay, eye defects, neurological problems, and blood abnormalities.
Peroxiredoxin 1 – an antioxidant enzyme in cancer - PMC
Peroxiredoxins (PRDXs), a ubiquitous family of redox‐regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant enzymes, PRDX1 can become easily over‐oxidized on its ...
Peroxiredoxin 1 - an antioxidant enzyme in cancer - PubMed
In this paper, we review the structure, effector functions of PRDX1, its role in cancer and the pivotal role of ROS in anticancer treatment.
Peroxiredoxin - Wikipedia
Peroxiredoxins (Prxs, EC 1.11.1.15; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine -induced peroxide levels and thereby mediate signal transduction in mammalian cells. The family members in humans are PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6.
Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via ...
Prdx1 deficiency increases macrophage foam cells in atherosclerotic plaques. To elucidate whether the impaired lipophagic flux caused by oxidative stress in Prdx1-deficient macrophages affects macrophage function, we first examined the lipoprotein uptake ability of macrophages.
Peroxiredoxin 1 and its role in cell signaling - PMC
Prdx1 prevents Akt-driven tumorigenesis through protecting PTEN lipid phosphatase activity from oxidation-induced inactivation. (A) Prdx1 regulates PTEN phosphatase activity during oxidative stress, since binding of Prdx1 and PTEN occurs in conditions of mild or nil cellular stress.
Dual role of PRDX1 in redox-regulation and tumorigenesis: Past …
2024年1月1日 · PRDX1 plays a dual role as both peroxidase and molecular chaperone. PRDX1 can be both tumour promotor and suppressor. PRDX1 inhibitors has proved antitumour efficacy in various cancer types. New technologies contribute to the development of PRDX1 inhibitors.
PRDX1 peroxiredoxin 1 - NIH Genetic Testing Registry (GTR)
2024年9月19日 · Membrane Bound Peroxiredoxin-1 Serves as a Biomarker for In Vivo Detection of Sessile Serrated Adenomas. PRDX1 gene-related epi-cblC disease is a common type of inborn error of cobalamin metabolism with mono- or bi-allelic MMACHC epimutations.
Peroxiredoxin1, a novel regulator of pronephros development
2017年8月21日 · Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H 2 O 2 and alkyl hydroperoxide and plays an important role in...
Role for Prdx1 as a specific sensor in redox-regulated ... - Nature
2013年1月21日 · Recent studies suggest that Peroxiredoxin 1 (Prdx1), in addition to its known H 2 O 2 -scavenging function, mediates cell signaling through redox-specific protein–protein interactions. Our data...
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent …
2021年8月13日 · Peroxiredoxin 1 (PRDX1) belongs to an abundant family of peroxidases whose role in cancer is still unresolved. While mouse knockout studies demonstrate a tumour suppressive role for PRDX1, in...
Peroxiredoxin-1 as a molecular chaperone that regulates …
2024年3月1日 · One of the identified proteins is PRDX1, also known as peroxiredoxin 1, which is a 23-kDa redox protein found in macrophages that is generated by stress and exhibits many activities. PRDX1 expression is correlated with reactive ROS …
Entry - *176763 - PEROXIREDOXIN 1; PRDX1 - OMIM
2022年11月3日 · PRDX1 is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. PRDX1 also reduces intramolecular cystine bridges (summary by Yan et …
Peroxiredoxin 1 – an antioxidant enzyme in cancer
2016年9月21日 · PRDX1 is proven to be a versatile molecule regulating cell growth, differentiation and apoptosis. Recent studies have found that PRDX1 and/or PRDX1-regulated ROS-dependent signalling pathways play an important role in the progression and metastasis of human tumours, particularly in breast, oesophageal and lung cancers.
Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via ...
This study reveals that PRDX1 is crucial to regulating lipophagic flux and maintaining macrophage cholesterol homeostasis against oxidative stress. We suggest that PRDX1-dependent control of oxidative stress may provide a strategy for treating atherosclerosis and …
Identification and verification of PRDX1 as an inflammation …
PRDX1, which belongs to the PRDX family, is composed of thiol-specific antioxidant enzymes that reduce H 2 O 2 and peroxynitrite [40, 41] and is associated with mitigation of oxidative damage [42]. PRDX1 has been proved to be overexpressed in breast cancer [43], malignant mesothelioma [44] and lung cancer [45].
Peroxiredoxin 1 interacts with and blocks the redox factor ... - Nature
2016年7月8日 · Our findings suggest that the interaction of PRDX1 with APE1 represents a novel anti-inflammatory function of PRDX1, whereby the association safeguards APE1 from reducing transcription...
Peroxiredoxin 1 modulates oxidative stress resistance and cell ...
2024年12月17日 · PRDX1 plays a crucial role in protecting HepG2 HCC cells from oxidative stress, with decreased levels correlating with heightened apoptosis, revealing its pivotal function in CSCs oxidative stress defense.