
PPARG Gene - GeneCards | PPARG Protein | PPARG Antibody
2024年12月25日 · PPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene. Diseases associated with PPARG include Lipodystrophy, Familial Partial, Type 3 and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and PIP3 activates AKT signaling.
PPARG peroxisome proliferator activated receptor gamma
Gene ID: 5468, updated on 9-Feb-2025. This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma.
PPARγ signaling and metabolism: the good, the bad and the …
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral medications for type 2 diabetes. However, their unique benefits are shadowed by the risk for fluid retention, weight gain, bone loss and congestive heart failure.
PPARγ signaling and metabolism: the good, the bad and the future
2013年5月7日 · Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral medications for...
Review of the Structural and Dynamic Mechanisms of PPAR
PPAR γ (peroxisome proliferator activated receptor γ) is a ligand activated transcription factor of the nuclear receptor superfamily that controls the expression of a variety of genes involved in fatty acid metabolism, adipogenesis, and insulin sensitivity.
PPARG peroxisome proliferator activated receptor gamma
2025年1月11日 · PPAR-gamma expression in peritoneal endometriotic lesions correlates with pain experienced by patients. Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. Ma XM, Yu H, Huai NMa XM, et al. World J Gastroenterol, 2009 Aug 21. PMID 19701967.
Peroxisome proliferator-activated receptor γ (PPARγ): A master ...
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-modulated transcription factor that governs the expression of genes involved in inflammation, redox equilibrium, trophic factor production, insulin sensitivity, and the metabolism of lipids and glucose.
PPARgamma in Metabolism, Immunity, and Cancer: Unified and …
2021年2月25日 · Since its identification in the early 1990s, PPARγ is best known for its critical role in adipocyte differentiation, maintenance, and function. Emerging evidence indicates that PPARγ is also important for the maturation and function of various immune system-related cell types, such as monocytes/macrophages, dendritic cells, and lymphocytes.
PPARG: Gene Expression Regulation and Next-Generation
Peroxisome proliferator-activated receptor gamma (PPARγ) is one of the most extensively studied ligand-inducible transcription factors (TFs), able to modulate its transcriptional activity through conformational changes.
PPARγ and TGFβ-Major Regulators of Metabolism, Inflammation, and ...
2021年9月28日 · Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor, initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism. It promotes lipid uptake and adipogenesis by increasing insulin sensitivity and adiponectin release.
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