This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity.

2024年12月25日 · POLR2A (RNA Polymerase II Subunit A) is a Protein Coding gene. Diseases associated with POLR2A include Neurodevelopmental Disorder With Hypotonia And Variable Intellectual And Behavioral Abnormalities and Skull Base Meningioma.

2021年11月24日 · RNA polymerase II subunit A (POLR2A) is the largest subunit encoding RNA polymerase II and closely related to cancer progression. However, the biological role and underlying molecular mechanism of POLR2A in gastric cancer (GC) are still unclear.

DNA-dependent RNA polymerase II (EC 2.7.7.6), a complex multisubunit enzyme, is responsible for the transcription of protein-coding genes. It is composed of 10 to 14 subunits ranging in size from 220 to 10 kD. POLR2A encodes the 220-kD subunit.

2024年1月15日 · ARMC5 is part of a novel ubiquitin ligase specific for POLR2A, the largest subunit of RNA polymerase II (Pol II). We find that ARMC5 knockout mice have increased incidence of NTDs, such as spina bifida and exencephaly.

Eukaryotic RNA polymerase I is essentially used to transcribe ribosomal RNA units, polymerase II is used for mRNA precursors, and III is used to transcribe 5S and tRNA genes. Each class of RNA polymerase is assembled from nine to fourteen different polypeptides.

POLR2A is the key catalytic subunit of RNA polymerase II that plays an irreplaceable role in gene expression. The expression regulation of POLR2A itself is vital for gene transcription in cells. Recent studies have also shown that POLR2A is closely related to …

2019年6月19日 · POLR2A serves as a major mediator for cellular senescence induced by XAB2 depletion. To gain deep insight into the physiological role of XAB2, we checked whether XAB2 could modulate cellular senescence.

This website provides information on patients with changes in the POLR2A gene (OMIM # 180660), including clinical data, molecular data, and management options. The syndrome caused by changes in the POLR2A gene is a multisystem disorder characterized by muscular, neurological, and behavioural abnormalities as well as a range of other symptoms.

Human Gene POLR2A (uc002ghf.4) Description: Homo sapiens polymerase (RNA) II (DNA directed) polypeptide A, 220kDa (POLR2A), mRNA. RefSeq Summary (NM_000937): This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes.