Dec 25, 2024 · PLOD2 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2) is a Protein Coding gene. Diseases associated with PLOD2 include Bruck Syndrome 2 and Bruck Syndrome. Among its related pathways are Collagen chain trimerization and Extracellular matrix organization.

In brief, this review about PLOD2 will describe the function, regulatory mechanism, and the inhibitors of PLOD2 in cancer, suggesting the credible clinical evaluation of a prognostic signature in pathological examination and the possible development of therapeutic strategies targeting PLOD2 in the future.

Mar 12, 2024 · ScRNA-seq analysis of these Hoxa11-CreERT2; Hif1afl/fl mice identified the PLOD2/LOX pathway for collagen cross-linking as downstream of the HIF-1α regulation of HO. Importantly, our scRNA-seq...

PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer. PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43. The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression.

Oct 26, 2017 · Gain- and loss-of-function studies and orthotopic implantation metastasis model pinpointed that PLOD2 promotes NSCLC metastasis directly by enhancing migration and indirectly by inducing collagen...

Jan 5, 2025 · PLOD2 Is a Prognostic Marker in Glioblastoma That Modulates the Immune Microenvironment and Tumor Progression. Kreße N, Schröder H, Stein KP, Wilkens L, Mawrin C, Sandalcioglu IE, Dumitru CAKreße N, et al .

Feb 15, 2025 · PLOD2 regulates PASMC proliferation and migration via PI3K/AKT signal and glycolysis. This study aimed to investigate the role and potential mechanism of procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) in chronic intermittent hypoxia (CIH)-induced mice and pulmonary arterial smooth muscle cells (PASMCs).

Here we report high expression of PLOD2 in oropharyngeal squamous cell carcinomas (SCCs) and its critical role as a stabilizer of integrin β1, enabling integrin β1 to initiate tumor invasion/metastasis.

Apr 8, 2013 · Valtavaara et al. (1997) reported the isolation and characterization of cDNA clones for a novel isoform, which they called lysyl hydroxylase-2, symbolized PLOD2. The predicted 737-amino acid polypeptide includes an N-terminal signal peptide and has overall similarity of more than 75% to lysyl hydroxylase-1, or PLOD1 ( 153454 ), from human and ...

Dec 26, 2024 · 本文将详细介绍PLOD2基因的表达模式及其在发育中的作用，包括通过RNA测序和芯片技术分析其在不同组织和发育阶段的表达情况，探讨其在胚胎发育、器官形成和细胞分化中的角色，以及研究其关键调控因子和功能验证。 PLOD2基因，也称为LH2或TLH，位于人类染色体3q24，属于Procollagen-lysine,2-oxoglutarate 5-dioxygenase家族。 这个基因编码的蛋白质在胶原蛋白的合成过程中起着关键作用，特别是在羟基化赖氨酸和羟基化脯氨酸的形成中。 通 …