Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene.

PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M phase of the cell cycle. PLK1-mediated phosphorylation of specific substrates controls cell entry into mitosis, centrosome maturation, spindl …

Dec 25, 2024 · PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include Gonococcal Keratitis and Epilepsy. Among its related pathways are Loss of proteins required for interphase microtubule organization from the centrosome and EML4 and NUDC in mitotic spindle formation.

Apr 1, 2006 · Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in cancer,...

The activities of several mitotic kinases, notably cyclin-dependent kinase 1 (Cdk1), Aurora kinases and polo-like kinase 1 (Plk1), are crucial for error-free chromosome segregation. From prophase to metaphase, Plk1 localizes to centrosomes and kinetochores and regulates different aspects of spindle assembly including bipolar spindle formation 1 .

In this article, we examined PLK1's structural characteristics, its regulatory roles in cell mitosis, PLK1 expression, and its association with survival prognoses of cancer patients in a wide variety of cancer types, PLK1 interaction networks, and PLK1 inhibitors under investigation.

Polo-like kinase 1 (Plk1), a well-characterized member of serine/threonine kinases Plk family, has been shown to play pivotal roles in mitosis and cytokinesis in eukaryotic cells. Recent studies suggest that Plk1 not only controls the process of ...

Jan 15, 2022 · PLK1 is a promising target for clinical treatment of diverse malignancies including ovarian cancer (OC), in which PLK1 over-expression is often correlated with poor prognosis and short survival. PLK1 can be blocked with small molecular inhibitors like volasertib (Vol) or silenced with PLK1-specific …

Mar 7, 2025 · PLK1 is overexpressed in prostate cancer and is one of the top five signalling pathways upregulated in castration-resistant prostate cancer, highlighting the importance of developing potent PLK1 inhibitors as a therapeutic strategy for prostate cancer. In this study, we successfully identified five novel and potent PLK1 inhibitors (Hits 1–5 ...

Feb 6, 2012 · Within the context of Plk1 phosphorylation of Orc2, we also emphasize regulation of Orc2 in different organisms. This review is intended to provide some insight into how Plk1 coordinates DNA replication in S phase with chromosome segregation in mitosis, and orchestrates the cell cycle as a whole.