PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M phase of the cell cycle. …

2024年12月25日 · PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include Gonococcal Keratitis and Epilepsy. Among its related pathways are Loss of …

In this article, we examined PLK1's structural characteristics, its regulatory roles in cell mitosis, PLK1 expression, and its association with survival prognoses of cancer patients in a wide …

2024年12月30日 · Polo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division, and its activity is tightly regulated throughout the cell …

In this review, we first discuss structure and function of PLK1, role of PLK1 in cancers, PLK1 specific inhibitors, and advantages of using combination therapy versus monotherapy followed …

2006年4月1日 · Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has …

PLK1, a serine/threonine protein kinase belonging to CDC5/Polo subfamily, plays a promotive role during mitosis. 21 As mentioned in the literature reviews, PLK1 regulates centrosome …

Polo-like kinase 1 (Plk1), a well-characterized member of serine/threonine kinases Plk family, has been shown to play pivotal roles in mitosis and cytokinesis in eukaryotic cells. Recent studies …

2025年3月7日 · PLK1 is overexpressed in prostate cancer and is one of the top five signalling pathways upregulated in castration-resistant prostate cancer, highlighting the importance of …

2025年3月3日 · The role of plk1 in the regulation of mitotic entry has been studied earlier, but the specific stage at which plk1 inhibition delays cells during mitotic entry, and generally whether …