
Polo-like kinase 1 (PLK1) signaling in cancer and beyond
PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M phase of the cell cycle. …
PLK1 Gene - GeneCards | PLK1 Protein | PLK1 Antibody
2024年12月25日 · PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include Gonococcal Keratitis and Epilepsy. Among its related pathways are Loss of …
PLK1, A Potential Target for Cancer Therapy - PubMed
In this article, we examined PLK1's structural characteristics, its regulatory roles in cell mitosis, PLK1 expression, and its association with survival prognoses of cancer patients in a wide …
Chk2 sustains PLK1 activity in mitosis to ensure proper ... - Nature
2024年12月30日 · Polo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division, and its activity is tightly regulated throughout the cell …
PLK1 inhibition-based combination therapies for cancer …
In this review, we first discuss structure and function of PLK1, role of PLK1 in cancers, PLK1 specific inhibitors, and advantages of using combination therapy versus monotherapy followed …
Targeting polo-like kinase 1 for cancer therapy - Nature
2006年4月1日 · Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has …
Identification and assessment of PLK1/2/3/4 in lung …
PLK1, a serine/threonine protein kinase belonging to CDC5/Polo subfamily, plays a promotive role during mitosis. 21 As mentioned in the literature reviews, PLK1 regulates centrosome …
Polo-like kinase 1, on the rise from cell cycle regulation to prostate ...
Polo-like kinase 1 (Plk1), a well-characterized member of serine/threonine kinases Plk family, has been shown to play pivotal roles in mitosis and cytokinesis in eukaryotic cells. Recent studies …
Discovery of a novel PLK1 inhibitor with high inhibitory potency …
2025年3月7日 · PLK1 is overexpressed in prostate cancer and is one of the top five signalling pathways upregulated in castration-resistant prostate cancer, highlighting the importance of …
PLK1 inhibition delays mitotic entry revealing changes to the ...
2025年3月3日 · The role of plk1 in the regulation of mitotic entry has been studied earlier, but the specific stage at which plk1 inhibition delays cells during mitotic entry, and generally whether …
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