Dec 25, 2024 · PLIN2 (Perilipin 2) is a Protein Coding gene. Diseases associated with PLIN2 include Sebaceous Adenocarcinoma and Meibomian Cyst. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and Selective autophagy. An important paralog of this gene is PLIN3.

May 25, 2022 · Here, we show that Plin2-mediated moderate lipid hydrolysis is critical for pluripotency of embryonic stem cells (ESCs). Upon exit from pluripotency, lipid droplet (LD)-associated protein Plin2...

Mechanistically, it is demonstrated that PLIN2 boosts HIF1α/SPP1 signaling in macrophages, thereby exerting pro-tumor functions. Finally, a PLIN2-targeting liposome is designed to efficiently suppress ascites production and tumor metastasis.

Although perilipin 2 (Plin2) has been shown to bind lipids with high affinity, the Plin2 lipid binding site has yet to be defined. This is of interest since Plin2’s affinity for lipids has been suggested to be important for lipid droplet biogenesis and intracellular triacylglycerol accumulation.

Jul 3, 2017 · Here we show that PLIN2 overexpression protects lipid droplets against macroautophagy/autophagy, whereas PLIN2 deficiency enhances autophagy and depletes hepatic TG.

May 6, 2019 · In this study, we hypothesized that deficiency in Plin2 would result in reduced myocardial lipid storage. In contrast to our hypothesis, we found increased accumulation of triglycerides in...

Jul 25, 2023 · Here, we performed a series of parallel CRISPR-Cas9 loss-of-function screens in a set of genome-edited PLIN2 reporter cells. These screens provide a phenotype-rich resource detailing the genetic modifiers that regulate PLIN2 and LDs, including regulators of PLIN2 expression and protein stability.

Feb 9, 2025 · PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia. Bildirici I, et al. Endocrinology, 2018 Dec 1. PMID 30351430, Free PMC Article. Potentially functional genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the ketone pathway and survival of nonsmall cell lung cancer.

May 8, 2023 · Our findings reveal the critical regulation of PLIN2 -induced ectopic lipid accumulation in phase-related muscle ageing plasticity. We initially determined the lifespan and changes in flight...

Here we show that PLIN2 overexpression protects lipid droplets against macroautophagy/autophagy, whereas PLIN2 deficiency enhances autophagy and depletes hepatic TG. The enhanced autophagy in plin2−/− mice protects against severe ER stress-induced hepatosteatosis and hepatocyte apoptosis.