2024年12月25日 · PLIN2 (Perilipin 2) is a Protein Coding gene. Diseases associated with PLIN2 include Sebaceous Adenocarcinoma and Meibomian Cyst. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and Selective autophagy. An important paralog of this gene is PLIN3.

Here we show that PLIN2 overexpression protects lipid droplets against macroautophagy/autophagy, whereas PLIN2 deficiency enhances autophagy and depletes hepatic TG. The enhanced autophagy in plin2−/− mice protects against severe ER stress-induced hepatosteatosis and hepatocyte apoptosis.

2024年11月17日 · Knockdown (KD) of lipid droplet (LD) protein perilipin 2 (PLIN2) in beta cells impairs glucose-stimulated insulin secretion (GSIS) and mitochondrial function. Here, we addressed a pathway responsible for compromised mitochondrial integrity in PLIN2 KD beta cells.

2022年5月25日 · Here, we show that Plin2-mediated moderate lipid hydrolysis is critical for pluripotency of embryonic stem cells (ESCs). Upon exit from pluripotency, lipid droplet (LD)-associated protein Plin2...

Although perilipin 2 (Plin2) has been shown to bind lipids with high affinity, the Plin2 lipid binding site has yet to be defined. This is of interest since Plin2’s affinity for lipids has been suggested to be important for lipid droplet biogenesis and intracellular triacylglycerol accumulation.

Mechanistically, it is demonstrated that PLIN2 boosts HIF1α/SPP1 signaling in macrophages, thereby exerting pro-tumor functions. Finally, a PLIN2-targeting liposome is designed to efficiently suppress ascites production and tumor metastasis.

2017年7月3日 · Of the corresponding gene products, PLIN2 is the only constitutive and ubiquitously expressed lipid droplet protein that has been used as a protein marker for lipid droplets. We and others reported that plin2-/-mice have an ∼60% reduction in TG content, and are protected against fatty liver disease. Here we show that PLIN2 overexpression ...

2025年2月7日 · PLIN2, a marker of macrophage LDs, is essential for cell survival under hypoxia and its expression can be stimulated by HIF1α in post-ischemic brain injury. However, the relationship between hypoxia and LDs requires further investigation.

2019年5月6日 · In this study, we hypothesized that deficiency in Plin2 would result in reduced myocardial lipid storage. In contrast to our hypothesis, we found increased accumulation of triglycerides in...

2023年7月25日 · Here, we leverage a set of genome-edited human PLIN2 reporter cell lines in a series of CRISPR-Cas9 loss-of-function screens, identifying genetic modifiers that influence PLIN2 expression and post-translational stability under different metabolic conditions and in different cell types.

2023年5月8日 · Our findings reveal the critical regulation of PLIN2 -induced ectopic lipid accumulation in phase-related muscle ageing plasticity. We initially determined the lifespan and changes in flight...

2023年9月25日 · Here, we leverage a set of genome-edited human PLIN2 reporter cell lines in a series of CRISPR-Cas9 loss-of-function screens, identifying genetic modifiers that influence PLIN2 expression and post-translational stability under different metabolic conditions and in different cell types.

2017年4月28日 · The perilipin proteins PLINs1–5 are the major LD-associated proteins (Table 1) [11, 12], and whereas PLIN1 is predominantly expressed in adipocytes, PLIN2 is expressed ubiquitously. Because PLIN1 and PLIN2 are located on LD particle surfaces, they are considered marker proteins for LDs.

We established that age-related PLIN2 expression in STEMI patients was higher compared to SA patients, merging the underlying mechanisms of PLIN2 expression to oxidative stress and inflammation-dependent metabolism pathways in coronary instability.

PLIN2 is the major perilipin regulated during sebocyte differentiation in vitro. PLIN2 is also important for sebaceous lipid accumulation in vitro and regulates sebaceous gland size in vivo. Our study provides the first systematic analysis of LD-associated proteins in sebocytes. Keywords: Sebaceous glands, Lipid droplets, Perilipins. 1.

2017年1月19日 · PLIN2 expression goes up when β cells are exposed to a lipid load or to chemical ER stress inducers. Downregulation of PLIN2 ameliorates the effects of fatty acid- and chemical-induced ER...

2018年5月1日 · PLIN2 (Perilipin-2) is a protein that can anchor on the membrane of lipid droplets (LDs), playing a vital role in the early formation of LDs and in the regulation of LD metabolism in many types of cells. However, little research has been conducted in cattle adipocytes.

Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy in adults, the incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), which was originally considered an RNA transcript, is markedly expressed during adipocyte differentiation.

2025年3月6日 · PLIN2 and PLIN3 were protein markers of cytoplasmic LDs, providing protection against degradation by cytoplasmic lipases and autophagosomes. However, they were target proteins of CMA. Our study confirmed that TFE3 fusion proteins can enhance CMA to degrade LDs-associated proteins, thus promoting the degradation of LDs.

Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy in adults, the incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), which was originally considered an RNA transcript, is markedly expressed during adipocyte differentiation.