A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. [1] [2] [3] It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin.

2020年5月6日 · Plexin家族蛋白是一种单次跨膜蛋白，由Plexin A (1-4), Plexin B (1-3), Plexin C1, Plexin D1四个亚家族组成，它们是神经引导分子（neuronal guidance molecule）Semaphorin的受体。区别于其它的单次跨膜受体，Plexin的胞内结构域有GAP活性（GTPase Activating Protein），能特异的催化Rap水解 ...

2020年2月5日 · Here we show that plexin D1 (PLXND1) has a role in mechanosensation and mechanically induced disease pathogenesis. PLXND1 is required for the response of endothelial cells to shear stress in...

2014年8月1日 · Several semaphorins and plexins are critically involved in tumour growth and metastasis by controlling tumour development and progression via the formation of autocrine signalling loops in cancer...

2025年2月1日 · Plexins are vital transmembrane receptors in nervous system development. Plexins are essential for neural development, axon guidance, and cell migration. There are four plexin subfamilies: A, B, C, and D, each with unique roles. Dysregulation of Plexin signaling links to autism, Alzheimer's, & more disorders.

2019年2月13日 · Plexins and semaphorins are cell surface receptors and ligands that regulate multiple processes of development and adult physiology, including neural development, vascular development, immune...

导向受体神经丛蛋白plexins是在轴突引导、肿瘤进展和免疫细胞调节中具有一系列重要功能的一类细胞受体。 已知plexins主要通过与配体（semaphorin ligands）结合，以结合细胞或游离状态与其他共受体一起发挥作用，从而激发细胞内信号传递，导致细胞骨架和细胞粘附一系列变化【2】。 2020年2月6日，来自英国牛津大学的Ellie Tzima的课题组在Nature上发表题为The guidance receptor plexin D1 is a mechanosensor in endothelial cells的文章。 该文章发现plexin …

2024年12月25日 · Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor.

Plexins are cell-surface receptors for the semaphorin family of neuronal guidance cues. Following semaphorin binding, the plexin cytoplasmic region initiates poorly understood signal-transduction events that lead to modifications of the cytoskeleton.

A Plexin is a type of transmembrane protein found in cells, characterized by the presence of a Sema domain at their N-terminus, a cysteine-rich motif in their extracellular region, and a plexin-specific domain in their cytoplasmic tail.