1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene. [5][6] From OMIM as of March 24, 2020: [7] Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups.

Dec 25, 2024 · PLCG2 (Phospholipase C Gamma 2) is a Protein Coding gene. Diseases associated with PLCG2 include Autoinflammation, Antibody Deficiency, And Immune Dysregulation and Familial Cold Autoinflammatory Syndrome 3 .

The PLCG2 gene provides instructions for making an enzyme called phospholipase C gamma 2 (PLCγ2). This enzyme performs a chemical reaction that enables molecules to relay signals from outside the cell to the inside.

Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule activated downstream from a variety of cell surface receptors that contain an intracellular immunoreceptor tyrosine-based activation motif.

Apr 22, 2019 · PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and PLAID-like diseases are rare, inherited immune disorders with overlapping features. An allergic response to cold, called cold urticaria, is the most distinct symptom.

PLCG2-associated antibody deficiency and immune dysregulation (PLAID) is an immune system disorder characterized by an allergic reaction to cold temperatures. Explore symptoms, inheritance, genetics of this condition.

Oct 13, 2020 · Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule activated downstream from a variety of cell surface receptors that contain an intracellular immunoreceptor tyrosine-based activation motif.

Oct 6, 2021 · PLCγ2 is a key component of intracellular signal transduction networks and induces Ca 2+ signals downstream of many myeloid cell surface receptors, including TREM2.

Apr 6, 2021 · See also the paragraph “PLCG2 variants: the Good, the Bad and the Ugly” for a review on the consequences of PLCγ2 loss of function (LOF) in peripheral immune cells. TREM2 and PLCγ2 signalling has been shown to regulate several immune functions in macrophages, promoting both pro- or anti-inflammatory responses, depending on cellular state ...

Jul 7, 2024 · Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells. Jing H, Reed A, Ulanovskaya OA, Grigoleit JS, Herbst DM, Henry CL, Li H, Barbas S, Germain J, Masuda K, Cravatt BFJing H, et al. Proc Natl Acad Sci …