2020年12月4日 · Platelet refractoriness is defined as a repeated suboptimal response to platelet transfusions with lower-than-expected posttransfusion count increments.

This topic discusses the causes, evaluation, and management of refractoriness to platelet transfusion, as defined below. Separate topics discuss: General principles of platelet transfusion – (See "Platelet transfusion: Indications, ordering, and associated risks".) Evaluation of thrombocytopenia.

Platelet transfusion refractoriness is the repeated failure to achieve the desired level of blood platelets in a patient following a platelet transfusion. The cause of refractoriness may be either immune or non-immune.

Platelet transfusion refractoriness (PTR), in which platelet counts do not increase after transfusion, occurs in many patients receiving platelet transfusions. PTR is a clinical condition that can harm patients. The causes of PTR can be divided into two types: immune and non-immune. Most cases of PTR are non-immune.

2023年5月11日 · Platelet refractoriness is defined as a suboptimal platelet count response after multiple platelet transfusions

2025年2月19日 · Patients with thrombocytopenia requiring on-going platelet transfusion support may develop inadequate platelet count increments, referred to as Platelet Refractoriness (PR), which further complicates their care.

2020年12月4日 · The majority of patients have nonimmune causes driving the refractoriness, such as bleeding, medications, or diffuse intravascular coagulation; however, this article is dedicated to the diagnosis and support of patients with immune-based platelet refractoriness.

This review will address a practical approach to the diagnosis and management of platelet refractoriness while highlighting on-going dilemmas and knowledge gaps. Keywords: alloimmunization; human leucocyte antigen antibodies; platelet transfusions.

This review will discuss the aetiology, diagnosis, and management of refractoriness to platelet transfusion, a complicated problem for both the treating physicians and the transfusion services supporting these patients.

Platelet refractoriness refers to the failure to achieve an adequate response to a platelet transfusion from at least two consecutive random donor transfusions. Two categories of causes of platelet refractoriness are immune and non-immune etiologies.