In this study, we investigated the clinical relevance of activated (phosphorylated) IGF-1 receptor (pIGF1R) expression in brain metastases originating from lung adenocarcinomas.

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1 …

2012年3月29日 · Insulin-like growth factor I receptor (Igf1r) signaling controls proliferation, differentiation, growth, and cell survival in many tissues; and its deregulated activity is involved …

2019年10月13日 · 一型胰岛素样生长因子受体（Type 1 insulin-like growth factor receptor， IGF1R）属于受体酪氨酸激酶家族（receptor tyrosine kinases， RTKs），胰岛素受体亚家 …

2016年6月29日 · Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT …

Consistently, treatment of TNFAIP8 knockdown cells with IGFBP3 siRNA restored pIGF1R and pAKT levels. TNFAIP8 knockdown cells had enhanced sensitivities to inhibitors of EGFR, …

2016年5月15日 · These data suggest that the absolute pIGF1R may regulate the levels of pAkt, which subsequently affects the development of LDD. The findings in the current study were …

2014年10月28日 · Previous studies have established the role of phosphorylated form of insulin-like growth factor type 1 receptor (p-IGF1R) as a good candidate for tumor biomarker. The …

Invitrogen Anti-Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Polyclonal, Catalog # 44-806G. Tested in Western Blot (WB) applications. This antibody reacts with Human, Mouse samples. …

2016年6月29日 · We evaluated the immunohistochemical (IHC) expression of p-IGF1R (Y1316) and MMP3 as predictors of PFS or overall survival (OS). Ninety-two advanced GIST patients …