In this study, we investigated the clinical relevance of activated (phosphorylated) IGF-1 receptor (pIGF1R) expression in brain metastases originating from lung adenocarcinomas.

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands.

2012年3月29日 · Insulin-like growth factor I receptor (Igf1r) signaling controls proliferation, differentiation, growth, and cell survival in many tissues; and its deregulated activity is involved in tumorigenesis. Although important during fetal growth and postnatal life, a function for the Igf pathway during preimplantation development has not been described.

2019年10月13日 · 一型胰岛素样生长因子受体（Type 1 insulin-like growth factor receptor， IGF1R）属于受体酪氨酸激酶家族（receptor tyrosine kinases， RTKs），胰岛素受体亚家族，位于细胞膜上，可以被胰岛素样生长因子（IGF1或IGF2）激活，引起自身酪氨酸激酶结构域的磷酸化并起始胞内信号传导，调控细胞的生长和分化，以及高等生物的生长、发育、衰老等各种生命活动。 大多数RTK在被配体激活之前以单体形式存在，配体诱使RTK二聚化，从而使酪氨酸结构 …

2016年6月29日 · Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT exon 11 mutated tumors. We evaluated the immunohistochemical (IHC) expression of p-IGF1R (Y1316) and MMP3 as predictors of PFS or overall survival (OS).

Consistently, treatment of TNFAIP8 knockdown cells with IGFBP3 siRNA restored pIGF1R and pAKT levels. TNFAIP8 knockdown cells had enhanced sensitivities to inhibitors of EGFR, PI3K, and AKT. Furthermore, IHC expression of TNFAIP8 was …

2016年5月15日 · These data suggest that the absolute pIGF1R may regulate the levels of pAkt, which subsequently affects the development of LDD. The findings in the current study were thus summarized in a schematic, showing that miR-4458 may suppress PI3k/Akt signaling pathway through 3’-UTR-inhibtion of IGF1R mRNA to promote development of LDD ( Figure 5 ).

2014年10月28日 · Previous studies have established the role of phosphorylated form of insulin-like growth factor type 1 receptor (p-IGF1R) as a good candidate for tumor biomarker. The aims of this study were to investigate p-IGF1R expression status in gastric cancer (GC) specimens and to clarify its clinical significance.

Invitrogen Anti-Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Polyclonal, Catalog # 44-806G. Tested in Western Blot (WB) applications. This antibody reacts with Human, Mouse samples. Supplied as 100 µL purified antibody.

2016年6月29日 · We evaluated the immunohistochemical (IHC) expression of p-IGF1R (Y1316) and MMP3 as predictors of PFS or overall survival (OS). Ninety-two advanced GIST patients included in GEIS-16 study with KIT and PDGFRA mutational information were examined for p-IGF1R (Y1316) and MMP3 expression in a tissue micro-array.