2024年12月25日 · PI4KB (Phosphatidylinositol 4-Kinase Beta) is a Protein Coding gene. Diseases associated with PI4KB include Deafness, Autosomal Dominant 87 and Enlarged Vestibular Aqueduct. Among its related pathways are Metabolism and PI Metabolism.

Phosphatidylinositol 4-kinase beta mutations cause nonsyndromic sensorineural deafness and inner ear malformation. Phosphatidylinositol 4-kinase III beta regulates cell shape, migration, and focal adhesion number.

2019年1月24日 · Phosphatidylinositol 4-kinase IIIβ (PI4KB) is a key enzyme of the Golgi system because it produces its lipid hallmark - the phosphatidylinositol 4-phosphate (PI4P).

2022年11月14日 · PI4KB inhibitors derived from the most potent PIK-93 scaffold with improved pharmacokinetic properties led to smaller primary tumours and fewer metastases in the contralateral lung in mice ...

2021年9月15日 · Phosphatidylinositol 4-kinase (PI4K) is a lipid kinase that can catalyze the transfer of phosphate group from ATP to the inositol ring of phosphatidylinositol (PtdIns) resulting in the phosphorylation of PtdIns at 4-OH sites, to generate phosphatidylinositol 4 …

2022年11月22日 · PI4KB generates PI4P at the Golgi and TGN, and it has important roles in membrane trafficking and cytokinesis. The 801 amino acid PI4KB protein is composed of a helical domain and a lipid kinase domain 146, as well as four disordered regions that mediate binding to regulatory proteins (Fig. 4b).

2019年1月24日 · Phosphatidylinositol 4-kinase IIIβ (PI4KB) is a key enzyme of the Golgi system because it produces its lipid hallmark - the phosphatidylinositol 4-phosphate (PI4P). It is recruited to Golgi by the Golgi resident ACBD3 protein, regulated by 14-3-3 proteins and it also serves as an adaptor because it …

Phosphatidylinositol 4-kinase IIIβ (PI4KB) is responsible for the synthesis of the Golgi and trans-Golgi network (TGN) pool of phosphatidylinositol 4-phospahte (PI4P). PI4P is the defining lipid hallmark of Golgi and TGN and also serves as a signaling lipid and as a precursor for higher phosphoinosi …

2025年1月1日 · PI4KB knockdown in zebrafish resulted in abnormal morphological vestibular organs (Feng et al., 2024). In this study, we identified gcPI4KB as a factor facilitating viral replication of GCRV, a double-stranded RNA virus, and suggested the involvement of gcPI4KB in the generation of GCRV VIBs.

The lipid kinase PI4KB, which generates phosphatidylinositol 4‐phosphate (PI4P), is a key enzyme in regulating membrane transport and is also hijacked by multiple picornaviruses to mediate viral replication. PI4KB can interact with multiple protein ...