6-phosphofructokinase, liver type (PFKL) is an enzyme that in humans is encoded by the PFKL gene on chromosome 21. [5] This gene encodes the liver (L) isoform of phosphofructokinase-1, an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism .

2024年12月25日 · PFKL (Phosphofructokinase, Liver Type) is a Protein Coding gene. Diseases associated with PFKL include Cholestasis, Benign Recurrent Intrahepatic, 2 and Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency.

2024年5月21日 · Upon nutrient stress in hepatocellular carcinoma, the glycolytic enzyme PFKL facilitates mitochondria tethering to lipid droplets to engage lipid mobilization and ensure nutrient supply.

2024年7月31日 · Here we show that phosphofructokinase 1, liver type (PFKL), a rate-limiting enzyme of glycolysis, is phosphorylated at Ser775 in macrophages following several innate stimuli.

Phosphofructokinase-1 (PFK1) is an essential glycolysis enzyme as it catalyzes the step committing glucose to breakdown. Webb et al. show that the liver PFK1 isoform assembles into filaments in a tetramer- and substrate-dependent manner, providing insights into the spatial organization of isoform-specific glucose metabolism in cells.

Gene ID: 5211, updated on 4-Jan-2025. This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis).

Here, we demonstrate that glucose deprivation induces phosphorylation of the glycolytic enzyme phosphofructokinase, liver type (PFKL), reducing its activity and favoring its interaction with perilipin 2 (PLIN2).

2018年11月8日 · Here we show that TAp73 stimulates the expression of phosphofructokinase-1, liver type (PFKL), which catalyzes the committed step in glycolysis. Through this regulation, TAp73 enhances glucose...

2021年8月19日 · PFKL is a negative regulator of the phagocytic oxidative burst. Its knockdown in neutrophils shifts the glycolytic flux to the pentose phosphate pathway, resulting in increased intracellular NADPH for use by NOX2 (Graham et al., 2015).

2021年8月19日 · A high-resolution structure of PFKL confirmed binding of NA-11 to the AMP/ADP allosteric activation site and explained why NA-11 failed to agonize phosphofructokinase-1 platelet type (PFKP) or muscle type (PFKM).