2024年12月25日 · PFKFB1 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1) is a Protein Coding gene. Diseases associated with PFKFB1 include Hepatocellular Carcinoma and Autism Spectrum Disorder. Among its related pathways are Glycolysis (REACTOME) and Integration of energy metabolism.

Results describe structural differences between two isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver and testis. This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes.

PFK-2/FBPase-2 is a bifunctional enzyme responsible for F-2,6-BP synthesis and degradation. Four isozymes of PFKFB (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) have been identified. Alterations in the levels of all PFK-2/FBPase-2 isozymes have been reported in different diseases.

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. [5] [6] This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes.

2024年3月5日 · Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

2025年2月20日 · Results describe structural differences between two isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver and testis. Enables several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity.

2023年11月2日 · Phosphofructokinase-fructose bisphosphatases (PFKFBs), a family of bidirectional glycolytic enzymes, modulate the formation and degradation of fructose-2,6-bisphosphate (F-2,6-BP), thereby regulating glycolysis [7]. PFKFBs is encoded by four genes (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) in humans [8].

2013年10月1日 · Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) enzymes are bi-functional enzymes encoded by four different genes (pfkfb1, pfkfb2, pfkfb3, pfkfb4) in vertebrates. They are involved in the regulation of glycolysis: they catalyze the synthesis and the degradation of F-2,6-BP (fructose-2,6-bisphosphate), the most potent allosteric ...

2024年12月10日 · View mouse Pfkfb1 ChrX:149371225-149426874 with: sequences, polymorphisms, proteins, references, function, expression

1998年3月2日 · The synthesis and degradation of fructose 2,6-bisphosphate are catalyzed by 6-phosphofructo-2-kinase (EC 2.7.1.105) and fructose-2,6-bisphosphatase (EC 3.1.3.46), respectively. In liver, these 2 activities belong to the same polypeptide encoded by the gene PFKFB1, which also encodes the muscle isozyme (summary by Hilliker et al., 1991).