Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a family of proteins present on the membrane surface of red blood cells (RBCs or erythrocytes) that are infected by the malarial parasite Plasmodium falciparum.

Jul 1, 2009 · PfEMP1 was shown to be a key molecule in defining the cytoadhesive properties of the iRBC to neighboring uninfected RBCs, forming structures called rosettes, as well as binding to several endothelial receptors.

Nov 17, 2022 · During the evolutionary arms race between the Plasmodium parasite and humankind, P. falciparum has evolved strategies to antagonize the function of IgM. Plasmodium falciparum erythrocyte...

Nov 15, 2001 · The malarial protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a parasite protein that is exported to the surface of the infected erythrocyte, where it is inserted into the red cell cytoskeleton in the second half of the parasite life cycle.

Apr 1, 2015 · PfEMP1 plays an important role in P. falciparum rosetting, which is a diverse adhesion phenotype that appears to involve multiple PfEMP1 ligands and several erythrocyte receptors (reviewed by Mercereau-Puijalon et al., 2008).

In this review, we will focus on the role of the P. falciparum membrane protein 1 (PfEMP1) family of VSA as targets of naturally acquired immunity and review their potential as vaccine targets. There have been extremely encouraging developments in this …

Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent.

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte membrane and mediate binding of infected erythrocytes to the endothelial lining of blood vessels.

We are studying the role of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed by asexual stages of P. falciparum responsible for the pathogenicity of severe malaria. The immunopathology of falciparum malaria has been linked to cyto-adhesion of infected erythrocytes to specific host receptors.

Nov 13, 2019 · PfEMP1 (or P. falciparum erythrocyte membrane protein 1) is the immunodominant IE surface antigen and binds multiple endothelial receptors, making it an attractive vaccine candidate.

Jan 5, 2025 · Here we report on the identification by single-cell reverse transcriptase PCR and cDNA cloning of the adhesive ligand P. falciparum erythrocyte membrane protein 1 (PfEMP1). Rosetting PfEMP1 contains clusters of glycosaminoglycan-binding motifs.

The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens, which mediates the adhesion of infected erythrocytes to the vascular endothelium in various tissues and organs, is a central component of the pathogenesis of the disease and a key target of the acquired immune response to malaria.

Jan 25, 2021 · Approximately 60 different Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by each haploid genome of P. falciparum, allowing this human malaria parasite to undergo antigenic variation and evade the immune system.

Sep 16, 2010 · The var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human endothelium. Antibodies blocking cytoadhesion are important mediators of malaria immunity acquired by endemic populations.

Apr 1, 2015 · PfEMP1 is a family of high-molecular weight proteins (approximately 200–450 kD) anchored in the surface membrane of P. falciparum -IEs. They are encoded by the ∼60 two-exon var genes in the haploid P. falciparum genome (Gardner et al., 2002).

Nov 15, 2001 · The malarial protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a parasite protein that is exported to the surface of the infected erythrocyte, where it is inserted into the red cell cytoskeleton in the second half of the parasite life cycle.

We investigated the immunosuppressive effect of PfEMP1 on monocytes/macrophages, which are central to the antiparasitic innate response. RAW macrophages and human primary monocytes were stimulated with wild-type 3D7 or CS2 parasites or transgenic PfEMP1-null parasites.

Prominent among them—and by far the best studied—is Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the clonally variant var gene family with approximately 60 members per parasite genome.

As the antibody response against the single expressed PfEMP1 develops, small sub-populations of parasites switch expression to alternative forms of PfEMP1 and re-establish the infection. Therefore, PfEMP1 is considered a key player in the pathogenicity of P. falciparum.

Jul 1, 2009 · PfEMP1 was shown to be a key molecule in defining the cytoadhesive properties of the iRBC to neighboring uninfected RBCs, forming structures called rosettes, as well as binding to several endothelial receptors.