Perforin-1 Perforin (PRF), encoded by the PRF1 gene, is a pore-forming toxic protein housed in the secretory granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Together, these cells are known as cytotoxic lymphocytes (CLs).

Perforin is a glycoprotein responsible for pore formation in cell membranes of target cells. Perforin is able to polymerize and form a channel in target cell membrane. Many research groups focus on the role of perforin in various diseases, immune ...

2015年5月22日 · Perforin and granzymes synergize to mediate apoptosis of target cells: pro-apoptotic granzymes diffuse through perforin pores on the plasma membrane of the target cell. Granzymes have various...

2024年12月25日 · PRF1 (Perforin 1) is a Protein Coding gene. Diseases associated with PRF1 include Hemophagocytic Lymphohistiocytosis, Familial, 2 and Lymphoma, Non-Hodgkin, Familial. Among its related pathways are Signaling by ALK fusions and activated point mutants and Granzyme Pathway.

Perforin is able to polymerize and form a channel in target cell membrane. Many research groups focus on the role of perforin in various diseases, immune response to bacterial and viral infections, immune surveillance and immunopathology.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

2025年2月12日 · Perforin’s interaction with granzymes is a finely orchestrated partnership enhancing its biological function. Granzymes, a family of serine proteases, are co-released with perforin from cytotoxic lymphocytes. While perforin breaches the target cell membrane, granzymes initiate apoptosis within these cells.

PRF1 (perforin 1) is a key cytotoxic molecule that plays a crucial role in the killing function of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Recent studies have focused on PRF1’s role in cancer development, progression, and prognosis.

Nevertheless, perforin is still the least studied and understood cytotoxic molecule in the immune system. In this review, we discuss the current state of affairs in the perforin field: the protein's structure and function as well as its role in immune-mediated diseases.

2022年2月11日 · Perforin is a pore-forming protein that facilitates rapid killing of pathogen-infected or cancerous cells by the immune system. Perforin is released from cytotoxic lymphocytes, together with proapoptotic granzymes, to bind to a target cell membrane where it oligomerizes and forms pores.