PER2 is a protein in mammals encoded by the PER2 gene. PER2 is noted for its major role in circadian rhythms. [5][6] The per gene was first discovered using forward genetics in Drosophilla melanogaster in 1971. Mammalian Per2 was discovered by in 1997 through a search for homologous cDNA sequences to PER1. [7] .

Modification of the Per2 clock gene in mPer2Luc reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased ...

Furthermore, the period circadian clock 2 (Per2) gene is an important component of the circadian clock, which modulates the circadian rhythm. Per2 is mainly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as other brain areas, including the …

PER2 Promotes Odontoblastic/Osteogenic Differentiation of Dental Pulp Stem Cells by Modulating Mitochondrial Metabolism. Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A beta-lactamase enzymes. PER2 integrates circadian disruption and pituitary tumorigenesis.

This review summarizes the research progress of PER2 in hematological malignancies, especially leukemia, in order to better understand its role in hematological malignancies, and provide new ideas for clinical diagnosis and treatment.

Virgin Per2-deficient mice, Per2 −/−, have underdeveloped glands, containing fewer bifurcations and terminal ducts than glands of wild-type mice. Using a transplantation model, we show that these changes are intrinsic to the gland and further identify changes in cell fate commitment.

2024年12月25日 · PER2 (Period Circadian Regulator 2) is a Protein Coding gene. Diseases associated with PER2 include Advanced Sleep Phase Syndrome, Familial, 1 and Advanced Sleep Phase Syndrome. Among its related pathways are Circadian Clock and Exercise-induced circadian regulation.

PER2 Protein is a protein encoded by the PER2 gene, which is a member of the Period gene family. It plays a crucial role in regulating circadian rhythms in the brain, including locomotor activity, metabolism, and behavior.

2025年2月8日 · Title: PER2 Promotes Odontoblastic/Osteogenic Differentiation of Dental Pulp Stem Cells by Modulating Mitochondrial Metabolism. Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A beta-lactamase enzymes.

2024年1月1日 · PER2 gene is a key component of the circadian clock, which regulates the rhythm. It has an effect on a range of neurological functions, including sleep and emotional behavior. As one of the fundamental components of the circadian clock, PER2 impacts everything from peripheral organs to the CNS.