Peptide YY is a short (36- amino acid) peptide released from cells in the ileum and colon in response to feeding. In the blood, gut, and other elements of periphery, PYY acts to reduce appetite; similarly, when injected directly into the central nervous system, PYY is also anorexigenic, i.e., it reduces appetite. [6]

Below we review studies examining the role of the gut hormone peptide YY in regulating body weight, the potential mechanisms by which PYY exerts its anorectic effects, the emerging evidence for a role of PYY in the weight loss benefits seen following gastric bypass surgery and the therapeutic potential of the PYY system for obesity.

Peptide YY (PYY) is a 36 amino acid peptide that is released in proportion to caloric intake from L cells primarily in the terminal ileum, colon and rectum, and the proximal ileum to a lesser extent [178]. PYY's functions include delayed gastric emptying and reduced gastric secretion.

Peptide YY is released after eating, circulates in the blood and works by binding to receptors in the brain. Binding of peptide YY to brain receptors decreases appetite and makes people feel full after eating. Peptide YY also acts in the stomach and intestine to slow down the movement of food through the digestive tract.

Peptide YY (PYY) plays a critical role in managing our feelings of fullness and hunger, known as satiety. This hormone is a key component in the complex regulatory system that helps balance our food intake.

2021年12月21日 · PYY is one of the major anorexigenic gastrointestinal neuroendocrine peptides (19). Upon release, PYY is metabolized by dipeptidyl peptidase-IV (DPP-IV) to PYY (3 – 36), which crosses the blood-brain barrier. There, it binds to Y2 receptors on NPY neurons in the arcuate nucleus of the hypothalamus.

2024年1月23日 · Peptide YY (PYY), a hormone produced by gut endocrine cells that was already known to control appetite, also plays an important role in maintaining the balance of fungi in the digestive system of mammals, according to new research from the University of Chicago.

Peripheral administration of PYY3-36 inhibits food intake for several hours in both rodents and man. The binding of PYY3-36 to the Y2 receptor leads to an inhibition of the NPY neurones and a possible reciprocal stimulation of the pro-opiomelanocortin neurones.

2022年11月25日 · Peptide YY (PYY) is a 36-amino acid peptide encoded by the PYY gene, first discovered in 1982 when it was isolated from porcine intestinal tissue (Takemoto 1982).

PYY release is stimulated by intraluminal nutrients, including glucose, bile salts, lipids, short-chain fatty acids and amino acids. Regulatory peptides such as cholecystokinin (CCK), vasoactive intestinal polypeptide (VIP), gastrin and GLP-1 modulate PYY release.