MORPHOLOGY OF PEPTIC ULCER Gross. Lesions less than 2 cm in diameter; classic peptic ulcer is a round to oval, sharply punched-out with sharply defined margins; The mucosal margin may overhang the base slightly, in contrast, heaped-up margins are more characteristic of …

2023年6月5日 · Peptic ulcer disease (PUD) is characterized by discontinuation in the inner lining of the gastrointestinal (GI) tract because of gastric acid secretion or pepsin. It extends into the muscularis propria layer of the gastric epithelium. It usually …

2025年2月14日 · Peptic ulcer disease (PUD) encompasses a number of entities, united by the presence of mucosal ulceration secondary to the effects of gastric acid. Since the recognition of Helicobacter pylori as a common causative agent and the development of powerful anti-acid medications, peptic ulcer disease has become comparatively rare in western populations.

A good example of this occurs in the upper gastrointestinal tract in the form of peptic ulcer disease involving the stomach and duodenum. These ulcers result from the presence of acid secreted by the mucosa of the stomach.

We now have an etiology for chronic gastritis that can be readily identified in histological sections using simple techniques. The accumulated knowledge of bacterial pathogenicity and the host response now offers plausible explanations for the tissue changes observed.

Different pathogenetic mechanism involved in gastric and duodenal ulcers. Mucosal digestion from hyperacidity and damage to mucosal barrier. This is due to. Gastric mucosal defense is broken down by bacterial urease, protease, catalase and phospholipase.

2020年6月20日 · Autopsy pictures and histology sections from a different patient with peptic ulcer disease are presented. Images

The clearest sign of peptic ulcer is ulcer foci and histopathological changes in the mucus. In all ulcer models, superficial or deep mucosal erosions occur, characterized by apoptosis and necrosis. The type of ulcer model determines the severity of histopathological damage.

2023年6月12日 · Peptic ulcer disease is defined as an insult to the mucosa of the upper digestive tract resulting in ulceration that extends beyond the mucosa and into the submucosal layers. Peptic ulcers most commonly occur in the stomach and duodenum though they can occasionally be found elsewhere (esophagus or Meckel diverticulum). [1] .

Chronic peptic ulcer (stomach) is a mucosal defect which penetrates the muscularis mucosae and muscularis propria, produced by acid-pepsin aggression. Ulcer margins are regular, slightly elevated due to adjacent chronic gastritis.