Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. [5][6] The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines.

2024年12月25日 · PDGFB (Platelet Derived Growth Factor Subunit B) is a Protein Coding gene. Diseases associated with PDGFB include Dermatofibrosarcoma Protuberans and Basal Ganglia Calcification, Idiopathic, 5. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

2025年3月4日 · Title: Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway. Platelet-Derived Growth Factor B Is a Key Element in the Pathological Bone Formation of …

The PDGFB gene provides instructions for making one version (isoform) of the platelet derived growth factor (PDGF) protein. This protein is involved in many cellular processes, including cell growth and division (proliferation), maturation (differentiation), and movement.

2025年1月23日 · PDGFB, which is involved in various immune responses, influences the malignant characteristics of various cancer types and controls immune cell infiltration. We confirmed that PDGFB positively correlated with CD8 and PDL1 expression in lower grade glioma.

PDGF is the major polypeptide mitogen in serum for cells of mesenchymal origin. Josephs et al. (1984) concluded that the SIS gene encodes 1 chain of human PDGF. PDGF has 2 dissimilar subunits, A and B. It is the B chain that has homology to SIS (Collins et al., 1985).

Platelet-Derived Growth Factors (PDGFs) are a family of four cystine-knot-type growth factors (PDGF-A, -B, -C and -D) which control the growth of connective tissue cells such as fibroblasts and smooth muscle cells [1, 2].

2025年1月11日 · Clinical resource with information about PDGFB, Basal ganglia calcification, idiopathic, 5, Familial meningioma, Idiopathic basal ganglia calcification 1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2023年5月1日 · Platelet-derived growth factors and their receptors involvement in drug resistance and oncogenesis. Crosstalk between PDGF/PGDFR signaling and other cellular signaling pathway in cancer progression. Therapeutic targeting of PDGF/PDGFR pathway via antibody and aptamer. Natural compounds as potent PDGFR/PDGFRs inhibitors.

Platelet-derived growth factor (PDGF) was purified from platelet extracts and characterized as a mitogen for fibroblasts and cells of mesenchymal origin in the late seventies. In humans, several dimeric isoforms are produced from four different genes, namely PDGF-A, -B and, more recently, …