Dec 25, 2024 · PCSK7 (Proprotein Convertase Subtilisin/Kexin Type 7) is a Protein Coding gene. Diseases associated with PCSK7 include Lymphoma and Apricot Allergy . Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity .

Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene. [5] [6] [7] The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products.

Jan 1, 2024 · PCSK7 is a novel post-translational chaperone/escort of apoB100. Loss of PCSK7 leads to proteasomal apoB degradation and prevents hepatic steatosis. Absence of PCSK7 leads to effective recovery of liver from diet-induced NAFLD. Hepatocyte-targeted GalNac-ASOs against Pcsk7 reduce apoB and reverse NAFLD.

PCSK7 is involved in sTfR generation and iron homeostasis. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.

野生型 (WT) 和Pcsk7 −/− 小鼠 通过 12 周的高脂肪/果糖/胆固醇饮食诱发非酒精性脂肪肝 (NAFLD)， 然后通过 4 周的对照饮食恢复。 Pcsk7-/− 小鼠比 WT 小鼠在所有 NAFLD 相关肝脏表型中恢复得更有效。最后，对WT小鼠皮下注射靶向肝Pcsk7的GalNAc-ASOs验证了上述结果。 结论

PCSK7 is the transmembrane protease acting in adipocyte differentiation [26] shown to impact obesity and related metabolic ailments, such as insulin resistance [27]. PCSK8 plays an important role in the regulation of lipid and cholesterol metabolism by cleaving sterol regulatory element-binding transcription factors (SREBP-1 and SREBP-2) [28, 29].

Discovered in 1996, PCSK7 is the seventh of the nine-membered proprotein convertase subtilisin-kexin (PCSK) family. This article reviews the various aspects of the multifaceted biology of PCSK7 and what makes it an exciting new target for metabolic dysfunction-associated steatotic liver disease (MAS …

该基因编码枯草杆菌蛋白酶样原蛋白转化酶家族的一个成员，其中包括通过分泌途径的受调节或组成性分支处理蛋白质和肽前体运输的蛋白酶。 它编码一种在许多组织中表达的 1 型膜结合蛋白酶，包括神经内分泌、肝脏、肠道和大脑。 编码的蛋白质在 ER 中经历初始自催化处理事件，然后通过核内体分类到反式高尔基体网络，在那里发生第二次自催化事件并获得催化活性。 该基因编码七个碱性氨基酸特异性成员之一，这些成员在单个或成对的碱性残基处切割其底物。 它可以处 …

Dec 11, 2024 · Discovered in 1996, PCSK7 is the seventh of the 9-membered proprotein convertase subtilisin-kexin (PCSK) family. This article reviews the various aspects of the multifaceted biology of PCSK7 and what makes it an exciting new target for metabolic dysfunction–associated steatotic liver disease (MASLD), affecting ∼30% of the population ...

Our data reveal hepatic PCSK7 as one of the major regulators of apoB, and its absence reduces apoB secretion from hepatocytes favoring its ubiquitination and degradation by the proteasome. This results in a cascade of events, eventually reducing hepatic lipid accumulation, thus supporting the notion …