2021年10月28日 · The results showed PCSK1, PCSK3, and PCSK5 to be the most closely related PCSK genes clustered into one clade with a high bootstrap value; whereas, PCSK9 and MBTPS1 were more distant to other PCSKs and constituted the periphery branches .

Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active.

2013年9月18日 · PCSK3, PCSK5, and PCSK6 process two triglyceride lipase family members, endothelial lipase and lipoprotein lipase, which are important for HDL remodeling. Recent studies in our lab found evidence that PCSK1 and PCSK9 are also involved in HDL metabolism.

Furin/PCSK3 protein is a ubiquitous endoprotease in the constitutive secretory pathway that efficiently cleaves the RX(K/R)R consensus motif. Its versatility is evident in processing TGFB1 (essential for TGF-β-1 activation) and converting the brain natriuretic factor prohormone into active BNP(1-32).

Furin has an inhibition peptide, which serves as an intramolecular chaperone, that is autocatalytically removed in the endoplasmic reticulum and remains non-covalently bound to furin as a potent autoinhibitor.

2023年4月26日 · Methods: We investigated the PCSK3 gene expression level in peripheral blood mononuclear cells isolated from Sjögren’s Syndrome (SS) patients and healthy controls and we evaluated a possible correlation with IFN-γ gene expression.

2024年12月25日 · FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme) is a Protein Coding gene. Diseases associated with FURIN include Cerebral Amyloid Angiopathy, Itm2b-Related, 1 and Diphtheria. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and HIV Life Cycle.

Objectives: Furin (Proprotein Convertase Subtilisin/Kexin Type 3, PCSK3) is a proprotein convertase involved in the pro - cessing of precursor proteins. Furin substrates play significant roles in the initiation and progression of atherosclerosis, which is the primary cause of coronary artery disease (CAD).

2013年8月6日 · This study dissected the impact and interplay of the PCSK family member furin (PCSK3) and its inhibitor serpinB8 in WAT inflammation and obesity. We demonstrate that acquisition of the invasive macrophage phenotype is driven by attenuation of serpinB8 and upregulation of furin, resulting in increased furin-like PCSK activity.

Results indicate that PCSK1 is found in all three regions of the SI while PCSK2 and PCSK3 are primarily expressed in the upper two, the duodenum and the jejunum.