Ubiquitinated-PCNA protects replication forks from DNA2 …
2020年5月1日 · Upon genotoxic stress, PCNA ubiquitination allows for replication of damaged DNA by recruiting lesion-bypass DNA polymerases. However, PCNA is also ubiquitinated …
Ubiquitination of PCNA and its essential role in eukaryotic ... - PubMed
Here, we will review the recent findings on translesion synthesis (TLS) and its regulation by PCNA ubiquitination in eukaryotes. We will discuss two prevalent models, i.e., the postreplicative gap …
Ubiquitination of PCNA and Its Essential Role in Eukaryotic
2011年4月3日 · In this review, we will focus on the ubiquitination of proliferating cell nuclear antigen (PCNA) and it role in eukaryotic translesion synthesis (TLS). PCNA is one of the …
Dynamic regulation of PCNA ubiquitylation/deubiquitylation
In this review, we focus on the ubiquitylation and deubiquitylation of Proliferating Cell Nuclear Antigen (PCNA), a homotrimeric ring that functions as a DNA polymerase sliding clamp …
Roles of sequential ubiquitination of PCNA in DNA-damage …
2011年9月16日 · Recent studies revealed that DDT in budding yeast is achieved through sequential ubiquitination of DNA polymerase processivity factor, proliferating cell nuclear …
ATAD5-BAZ1B interaction modulates PCNA ubiquitination …
2024年12月3日 · Our research reveals that BAZ1B, a regulatory subunit of the BAZ1B-SMARCA5 chromatin-remodeling complex (also known as the WICH complex), plays a crucial role in fine …
PCNA-Ub polyubiquitination inhibits cell proliferation and induces …
2016年10月18日 · In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue leading to 2 modes of DNA …
PCNA-Ub polyubiquitination inhibits cell proliferation and
2016年12月16日 · In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue leading to 2 modes of DNA …
PCNA cycling dynamics during DNA replication and repair in …
2024年6月1日 · Poly-Ub-PCNA recruits SLX4 and SLX4-interacting nucleases to increase telomeric DNA synthesis. These results suggest that regulation of the PCNA ubiquitination …
PCNA Ubiquitination and REV1 Define Temporally Distinct …
Our finding that REV1 and PCNA ubiquitination function at temporally distinct points relative to replication fork arrest not only accords with the epistasis analysis of TLS polymerase and …