Antibodies against proliferating cell nuclear antigen (PCNA) or a similar marker of proliferation termed Ki-67 can be used for grading of different neoplasms, e.g. astrocytoma. They can be of diagnostic and prognostic value.

PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast, plant and animal cells that undergo cell division, suggesting a function in cell cycle regulation and/or DNA replication. It subsequently became clear that PCNA also ...

2016年6月6日 · The function of Ki67, the widely used marker of proliferation, still remains unclear. In contrast, PCNA and MCM proteins have been identified as important participants of DNA replication. All three proteins only manifest their expression during the cell division of normal and neoplastic cells.

In this paper, we clearly state that Ki-67 is a more specific proliferation marker than PCNA for ameloblastic tumors. It also should be recognized that a marker of cell proliferation can enable an understanding of how cell division works.

In this study, we aimed to investigate the significance of PCNA expression in NSCLC tissues. PCNA expression in NSCLC and adjacent tissues were assessed by immunohistochemistry (IHC), western blotting, and reverse transcription polymerase chain reaction.

Proliferating cell nuclear antigen (PCNA) is an evolutionarily well-conserved protein found in all eukaryotic species as well as in Archaea. PCNA was first shown to be involved in DNA replication.

Proliferating Cell Nuclear Antigen (PCNA) is a nuclear protein that serves as a crucial biomarker for cell proliferation and DNA maintenance. This protein plays an essential role in DNA replication and repair processes, making it a valuable indicator of cellular activity in both normal and pathological conditions.

2016年6月1日 · This review provides information about the most well evaluated cell proliferation markers, namely Ki67, proliferating cell nuclear antigen (PCNA), and minichromosome maintenance (MCM) proteins, and describes their advantages and limitations when used in the diagnosis of breast cancer.

Proliferating cell nuclear antigen (PCNA) is known as a molecular marker for proliferation given its role in replication. Three identical molecules of PCNA form a molecular sliding clamp around the DNA double helix.

2006年11月19日 · In the current study, we demonstrate that PCNA is subject to tyrosine phosphorylation at a specific site and that the phosphorylation enhances PCNA stability on the chromatin. Our results link...