2022年4月11日 · Super-resolution imaging and colocalization analysis revealed that protein aggregates (pHSP27, Ub + and p62), satellite proteins (PCM1 and PIBF1) and CP110 occupy overlapping domains within the...

Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 19856-1-AP (PCM1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). Ready-to-use IHC kits available with PCM1 antibody included

2018年3月26日 · PCM1 is also a target of the ubiquitin-proteasome system (UPS). In growing cells, ubiquitylation of PCM1, AZI1, and CEP290 by the E3 ligase MIB1 suppresses primary cilium formation.

2022年4月11日 · Centrosomes are membrane-free organelles comprised of a pair of cylindrical structures (centrioles) embedded in a protein-rich matrix (PCM), which is the site of microtubule nucleation. Since 1998,...

2024年12月25日 · PCM1 (Pericentriolar Material 1) is a Protein Coding gene. Diseases associated with PCM1 include Differentiated Thyroid Carcinoma and Thyroid Cancer, Nonmedullary, 1. Among its related pathways are Loss of proteins required for interphase microtubule organization from the centrosome and Cell Cycle, Mitotic.

2019年1月1日 · In this study, we find that the deubiquitylase USP9X binds PCM1, and antagonizes PCM1 ubiquitylation to protect it from proteasomal degradation. Knockdown of USP9X in human cell lines reduces PCM1 protein levels, disrupts centriolar satellite particles and causes localization of satellite proteins, such as CEP290, to centrosomes.

2022年4月1日 · Protein degradation is critical to maintaining cellular homeostasis, and perturbation of the ubiquitin proteasome system leads to the accumulation of protein aggregates. These aggregates are either...

Download scientific diagram | Association of PCM1 with the E3 ubiquitin ligases MIB1 and WWP2. Co-localization of (A) PCM1 (red) with MIB1 (green) and (B) PCM1 (red) with WWP2 (green) by ...

Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

2023年12月8日 · 背景：最近的研究证实了中心粒周材料 1 (PCM1) 在几种恶性肿瘤细胞系中的作用，但其在肺腺癌 (LUAD) 中的具体生物学功能仍不清楚。 目的：为了解决这一差距，本研究分析了 411 个 LUAD 和对照样本，以使用 Cox 回归分析评估 PCM1 的预后价值。 方法：还分析了与 PCM1 共表达的多个基因，以研究 PCM1 所涉及的生物学过程和作用。 构建以PCM1为关键基因的内源竞争网络，揭示其在LUAD中的调控和竞争关系。 该研究基于免疫浸润分析，进一步探讨 …