The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box.

PAX-5, a transcription factor expressed throughout B-cell maturation, is detected in most B-cell neoplasms including those that lack expression of mature B-cell markers, such as classical Hodgkin lymphoma (cHL), B-lymphoblastic leukemia …

2024年12月25日 · PAX5 (Paired Box 5) is a Protein Coding gene. Diseases associated with PAX5 include Leukemia, Acute Lymphoblastic 3 and B-Lymphoblastic Leukemia/Lymphoma With T (7;9) (Q11.2;P13.2). Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative complex.

PAX-5 is the most sensitive and reliable immunohistochemical marker for B-cell malignancies (Dong et al., 2008). The nuclear positivity of PAX-5 makes it different from other pan B cells markers (CD20 and CD79a) which are membrane markers (Dong et al., 2008).

Pax5, or B-cell-specific activator protein, is a nuclear protein in the paired-box containing (PAX) family of transcription factors involved in control of organ development and tissue differentiation.

2023年5月21日 · PAX5 (Paired box protein 5) is a type of protein called a transcription factor that plays an important role in the development and function of B cells.

2007年4月17日 · Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role for Pax5 in controlling the identity and function of B cells throughout B lymphopoiesis.

Retrovirally expressed human Pax-5 protein activates endogenous early B-cell-specific mb-1 genes in mouse plasmacytoma cells, but only when the promoter is hypomethylated. Pax-5 is a key regulator of the B-cell-restricted expression of the CD23a isoform.

At B cell commitment, Pax5 restricts the developmental potential of lymphoid progenitors to the B cell pathway by repressing B-lineage-inappropriate genes, while it simultaneously promotes B cell development by activating B-lymphoid-specific genes.

2011年12月15日 · Given the pivotal importance of Pax-5 –mediated processes in B-cell development, an aberrant regulation of Pax5 expression has consistently been associated with B-cell cancers, namely, lymphoma and lymphocytic leukemias.