2024年12月25日 · PARK7 (Parkinsonism Associated Deglycase) is a Protein Coding gene. Diseases associated with PARK7 include Parkinson Disease 7, Autosomal Recessive Early …

The PARK7 gene provides instructions for making the DJ-1 protein. This protein is found in many tissues and organs, including the brain. Studies indicate that the DJ-1 protein has several …

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Mutations in the PD-associated gene PARK7 alter the structure and function of the encoded protein DJ-1, and the resulting autosomal recessively inherited disease increases the risk of …

PARK7 (DJ-1) is an evolutionary conserved gene that is abundantly expressed in brain and other tissues, and encodes a 189 amino acid protein. Loss-of-function, recessive PARK7 mutations …

PARK7 activates various intracellular signaling pathways that have been implicated in the induction of tumor progression, which subsequently enhances tumor initiation, continued …

2022年1月25日 · Here we report that PARK7, an enzyme mutated in hereditary Parkinson's disease, prevents damage of proteins and metabolites caused by a metabolite of glycolysis. …

DJ-1, encoded in a causative gene of familial Parkinson's disease (PARK7), has multiple functions: it works as an antioxidant, in transcriptional regulation, as a molecular chaperone …

2025年2月9日 · PARK7/DJ-1 inhibition decreases invasion and proliferation of uveal melanoma cells. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. DJ-1 …