
PAK4 - Wikipedia
PAK4 regulates cellular processes by its scaffolding activity and/or by phosphorylation of effector substrates, which in-turn, set-up a cascades of biochemical events cumulating into a cellular …
PAK4 signaling in health and disease: defining the PAK4–CREB …
2019年2月12日 · In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis.
PAK4 p21 (RAC1) activated kinase 4 [ (human)] - National Center …
2025年2月8日 · PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may …
PAK4 signaling in health and disease: defining the PAK4–CREB axis
In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis. Subject terms: …
PAK4 Gene - GeneCards | PAK4 Protein | PAK4 Antibody
2024年12月25日 · PAK4 (P21 (RAC1) Activated Kinase 4) is a Protein Coding gene. Diseases associated with PAK4 include Prostate Cancer and Autosomal Recessive Nonsyndromic …
PAK4 phosphorylates and inhibits AMPKα to control glucose …
2024年8月10日 · We demonstrate that PAK4 promotes insulin resistance by phosphorylating AMPKα2 at Ser491, thereby inhibiting AMPK activity. We additionally show that skeletal …
The significance of PAK4 in signaling and clinicopathology: A review
PAK4 facilitates the binding of TRADD to TNFR1 while inhibiting apoptosis under TNF-α inducement and NF-κB mediation. Moreover, PAK4 activates both PI3K/Akt and MEK/ERK …
The role of PAK4 in the immune system and its potential …
2021年9月1日 · PAK4 overexpression is a predictive biomarker for tumor development and resistance to cancer treatments. PAK4 is also a regulator of the anti-tumor immune response. …
PAK4–6 in cancer and neuronal development - PMC
PAKs 4, 5 and 6 are members of the group B family of p21-activated kinases. Among this group, PAK4 has been most extensively studied. While it has essential roles in embryonic …
PAK4: a pluripotent kinase that regulates prostate cancer cell …
2010年5月5日 · Our results suggest that PAK4 is a pluripotent kinase that can regulate both actin cytoskeletal rearrangement and focal-adhesion dynamics. Keywords: PAK, Migration, Prostate …
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