PAK4 regulates cellular processes by its scaffolding activity and/or by phosphorylation of effector substrates, which in-turn, set-up a cascades of biochemical events cumulating into a cellular phenotypic response.

2019年2月12日 · In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis.

2025年2月8日 · PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton.

In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis. Subject terms: Cell signalling, Experimental models of disease, Cell death in the nervous system.

2024年12月25日 · PAK4 (P21 (RAC1) Activated Kinase 4) is a Protein Coding gene. Diseases associated with PAK4 include Prostate Cancer and Autosomal Recessive Nonsyndromic Deafness 108. Among its related pathways are Integrin Pathway and …

2024年8月10日 · We demonstrate that PAK4 promotes insulin resistance by phosphorylating AMPKα2 at Ser491, thereby inhibiting AMPK activity. We additionally show that skeletal muscle-specific expression of a...

PAK4 facilitates the binding of TRADD to TNFR1 while inhibiting apoptosis under TNF-α inducement and NF-κB mediation. Moreover, PAK4 activates both PI3K/Akt and MEK/ERK pathways, thus having an effect on NF-κB so as to inhibit apoptosis. PAK4 promotes oncogenic transformation (bottom left).

2021年9月1日 · PAK4 overexpression is a predictive biomarker for tumor development and resistance to cancer treatments. PAK4 is also a regulator of the anti-tumor immune response. Targeting PAK4 would regulate immune cells response to anti-PD-1/anti-PD-L1 immune checkpoint inhibition therapy.

PAKs 4, 5 and 6 are members of the group B family of p21-activated kinases. Among this group, PAK4 has been most extensively studied. While it has essential roles in embryonic development, in adults high levels of PAK4 are frequently associated with cancer.

2010年5月5日 · Our results suggest that PAK4 is a pluripotent kinase that can regulate both actin cytoskeletal rearrangement and focal-adhesion dynamics. Keywords: PAK, Migration, Prostate cancer.