PAK4 regulates cellular processes by its scaffolding activity and/or by phosphorylation of effector substrates, which in-turn, set-up a cascades of biochemical events cumulating into a cellular …

2019年2月12日 · In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis.

2025年2月8日 · PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may …

In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis. Subject terms: …

2024年12月25日 · PAK4 (P21 (RAC1) Activated Kinase 4) is a Protein Coding gene. Diseases associated with PAK4 include Prostate Cancer and Autosomal Recessive Nonsyndromic …

2024年8月10日 · We demonstrate that PAK4 promotes insulin resistance by phosphorylating AMPKα2 at Ser491, thereby inhibiting AMPK activity. We additionally show that skeletal …

PAK4 facilitates the binding of TRADD to TNFR1 while inhibiting apoptosis under TNF-α inducement and NF-κB mediation. Moreover, PAK4 activates both PI3K/Akt and MEK/ERK …

2021年9月1日 · PAK4 overexpression is a predictive biomarker for tumor development and resistance to cancer treatments. PAK4 is also a regulator of the anti-tumor immune response. …

PAKs 4, 5 and 6 are members of the group B family of p21-activated kinases. Among this group, PAK4 has been most extensively studied. While it has essential roles in embryonic …

2010年5月5日 · Our results suggest that PAK4 is a pluripotent kinase that can regulate both actin cytoskeletal rearrangement and focal-adhesion dynamics. Keywords: PAK, Migration, Prostate …