Malignant cells known as Paget cells are a telltale sign of Paget disease of the breast. These cells are found in the epidermis (surface layer) of the skin of the nipple and the areola. Paget cells often have a large, round appearance under a microscope; they may be found as single cells or as small groups of cells within the epidermis.

Paget's disease of the breast is characterized by Paget cells: large cells with clear cytoplasm (clear halo) and eccentric (not centered), hyperchromic (darkly colored) nuclei found throughout the epidermis.

2023年6月3日 · The histologic hallmark of PDB is the presence of Paget cells, which are malignant, intraepithelial adenocarcinoma cells of variable sizes usually large in size, present singly or in the form of small groups within the epidermis of the nipple.

2021年5月20日 · Paget's (PAJ-its) disease of the breast is a rare form of breast cancer. Paget's disease of the breast starts on the nipple and extends to the dark circle of skin (areola) around the nipple. Paget's disease of the breast isn't related to Paget's disease of the bone, a …

Paget's disease of the breast is characterized by distinctive cancer cells on the skin of the nipple that can be seen under a microscope. Because Paget originally described them, they’re known as Paget cells.

Named after the observations of Sir James Paget. Characterized by presence of malignant glandular epithelial cells within the squamous epithelium of the nipple; Associated with invasive and insitu carcinoma breast; Pathogenesis – Two hypothesis. Mostly accepted hypothesis: Local migration of underlying carcinoma cells into lactiferous ducts

Paget's disease of the breast is a rare type of cancer of the nipple–areola complex and that is often associated with an underlying in situ or invasive carcinoma. This article provides an overview and we review the main clinicopathological and therapeutic features of mammary Paget's disease. Keywords: Breast, nipple, Paget's disease.

Paget disease of the breast is a rare type of breast cancer involving the skin of the nipple and the areola. Learn signs/symptoms & how it's diagnosed and treated.

Learn about Paget disease of the breast, also called Paget's disease, Paget disease of the nipple, and mammary Paget disease, including symptoms, treatment, diagnosis, and survivor care.

2021年12月26日 · clear cells with large, pleomorphic nuclei that spread individually into the epidermis ("pagetoid")