Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene. [5] [6] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity.

2024年12月25日 · PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2) is a Protein Coding gene. Diseases associated with PTPN2 include Oligoarticular Juvenile Idiopathic Arthritis and Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis.

PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 effects in different types of tumors makes it a potential target for tumor immunotherapy. Keywords: PTPN2, inflammation, tumor immunotherapy. 1. Introduction.

2023年10月4日 · Here we present the discovery and characterization of ABBV-CLS-484 (AC484), a first-in-class, orally bioavailable, potent PTPN2 and PTPN1 active-site inhibitor. AC484 treatment in vitro...

High PTPN2 Expression Was Independent Predictive Factors for Poor Outcomes in Pancreatic Adenocarcinoma Patients. Recently, PTPN2 has been identified as a potential target for cancer treatment.

2017年7月19日 · In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 inhibition may potentiate the ...

2025年2月12日 · PTPN2 (protein tyrosine phosphatase nonreceptor type 2) is an important member of the protein tyrosine phosphatase (PTP) family. It plays a crucial role in dephosphorylating tyrosine-phosphorylated proteins and modulating critical signaling pathways associated with T-cell receptors, IL-2, IFNγ, and various cytokines.

2024年5月29日 · Genetic deletion of PTPN2 in either tumor cells or host immune cells promotes the anti-tumor immunity. In addition, PTPN2 inhibitors, alone or in combination with anti-PD1 therapy, significantly reduced tumor growth and enhanced survival in several subcutaneous tumour models.

2022年9月2日 · PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 effects in different types of tumors makes it a potential target for tumor immunotherapy.

Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), an important member of the protein tyrosine phosphatase family, can regulate various signaling pathways and biological processes by dephosphorylating receptor protein tyrosine kinases.