Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family. In humans it is encoded by the PTPN1 gene. [5] .

2024年12月25日 · PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) is a Protein Coding gene. Diseases associated with PTPN1 include Type 2 Diabetes Mellitus and Bubonic Plague. Among its related pathways are Activation of cAMP-Dependent PKA and Gene expression (Transcription).

2023年10月4日 · Here we present the discovery and characterization of ABBV-CLS-484 (AC484), a first-in-class, orally bioavailable, potent PTPN2 and PTPN1 active-site inhibitor. AC484 treatment in vitro...

Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte. Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity. A Conserved Local Structural Motif Controls the Kinetics of PTP1B Catalysis.

PTPN1 (also known as PTP1B), a prominent member of the PTPNs, has been identified as a negative modulator of insulin and leptin receptor signaling (16). Recent evidence demonstrated that the role of PTPN1 varies with tumor types and can act …

PTPN1 haploinsufficiency causes a type 1 IFN-driven autoinflammatory encephalopathy. Notably, some patients demonstrated stabilisation, and even recovery, of neurological function in the absence of treatment, whereas in others, the disease …

2023年10月23日 · PTPN1 was overexpressed in multiple cancer types and correlated with the clinical outcome and tumor immunity, suggesting it could be a valuable potential prognostic and immunological biomarker for pan-cancer.

2025年1月4日 · Title: PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension. Computational analysis of PTP-1B site-directed mutations and their structural binding to potential inhibitors.