PTGS2 (COX-2), converts arachidonic acid (AA) to prostaglandin endoperoxide H2. PTGSs are targets for NSAIDs and PTGS2 (COX-2) specific inhibitors called coxibs. PTGS-2 is a sequence homodimer.

Dec 25, 2024 · PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.

Herein, we review the main effects of this molecular pathway in a tissue-specific manner, with a special emphasis on beta cell mass protection/destruction and its potential role in the prevention or development of T1DM. We also discuss strategies to target this pathway for future therapies.

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution.

Very important pharmacogene: PTGS2. This PharmGKB summary briefly discusses the PTGS2 gene and current understanding of its function, structure, regulation, and pharmacogenomic relevance. We also present three variants with pharmacogenomic significance and highlight the gaps in our knowledge of PTGS2-drug interactions. Overview

COX-2 is the product of prostaglandin-endoperoxide synthase 2 (PTGS2) gene expression. COX-2 dysregulation can cause angiogenesis, differentiation, and promotion of cancer and its suppression related to control of the tumor's size, number, and cell shape.

Sep 14, 2016 · Gene target information for PTGS2 - prostaglandin-endoperoxide synthase 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Mar 12, 2025 · PTGS2, a key enzyme in PGE2 synthesis, is considered one of the key factors regulating ferroptosis . The induction of disease by PTGS2 through mediating ferroptosis has been well reported in cardiovascular diseases . Ferroptosis is a nontraditional form of programmed cell death characterised by iron overload and lipid peroxidation . Ferroptosis ...

Aug 6, 2023 · The inducible Prostaglandin Endoperoxide Synthase 2/Cyclooxygenase 2 (PTGS2/COX2) plays an important role in pathologies associated with inflammatory signaling. The main product derived from PTGS2/COX2 expression and …

May 22, 2024 · Prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2) acts as an oncogenic driver in CRC. Here, we explored the upstream transcription factors (TFs) responsible...

Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response (By similarity). Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism.

Jan 5, 2025 · Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution.

The PTGS2 gene codes for the cyclooxygenase-2 (COX-2) enzyme that catalyzes the committed step in prostaglandin (PG) synthesis. Various in-vivo and in-vitro data suggest that prostaglandin E2 mediates as a signaling molecule for activating the VEGF ...

May 1, 2024 · PTGS2 (encode COX2) is related to inflammatory pathway and immune cell infiltration. COX2 inhibitor celecoxib suppressed mast cell degranulation and allergic reactions. Targeting PTGS2 may provide new ideas for chronic spontaneous urticaria treatment.

Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response (PubMed:22942274). Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism.

Feb 8, 2025 · PTGS2: A potential immune regulator and therapeutic target for chronic spontaneous urticaria. Abnormal Microglial Density and Morphology in the Brain of Cyclooxygenase 2 Knockin Mice. Genetic model of selective COX2 inhibition improve learning and memory ability and brain pathological changes in 5xFAD mouse.

Nov 29, 2024 · LTA stimulation significantly increases ER stress and apoptosis-related factors in MAC-T. Further analysis suggests that the increase in ER stress may be associated with interactions involving PTGS2 and GRP78. Protein structural studies indicate a strong interaction between PTGS2 and GRP78.

Sep 1, 2023 · Various in-vivo and in-vitro data suggest that prostaglandin E2 mediates as a signaling molecule for activating the VEGF signaling pathway (VSP), forming an association between COX-2 and VSP. Several chemotherapy regimens increasingly rely on preventing the synthesis of PGs.

Dec 19, 2023 · PTGS2 is the human gene encoding cyclooxygenase 2, which is a key enzyme mediating inflammation in vivo. It is induced by a variety of factors, such as cytokines, growth factors, and tumor-promoting factors, and plays an important role in inflammation and many cardiovascular diseases [9, 10].

The prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2 (COX-2), is an enzyme encoded by the PTGS2 gene. It plays a role in the conversion of arachidonic acid into prostaglandin H 2, which is further transformed into five primary prostaglandins (PGD2, PGE2, PGF2α, PGI2, and TXA2) by cell-specific synthases (36).