2024年12月25日 · PTGS1 (Prostaglandin-Endoperoxide Synthase 1) is a Protein Coding gene. Diseases associated with PTGS1 include Gastric Ulcer and Urticaria. Among its related pathways are Fatty acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and dioxygenase activity. An important paralog of this gene is ...

2023年11月24日 · We found that Ptgs1 -mediated epithelial prostaglandin production is the key event for in vivo partial reprogramming, which directly renders intestinal epithelial cells to adopt fetal characteristics without involving any mesenchymal assistance.

PTGS1 polymorphism may result in an elevated risk of colorectal adenomas. Inducible PGHS-1 gene expression involves the coordinate functioning of a Sp1 site in the promoter and an AP-1 site in intron 8.

Learn about the PTGS1 gene, also known as COX-1, its function in prostaglandin synthesis, its regulation, and its role in various diseases. Explore its inhibitors and therapeutic implications.

2011年1月11日 · PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation.

PTGS1, which is ubiquitously and constitutively expressed in mammalian tissues, plays an important role in the homeostasis of many physiological processes. However, PTGS2, which is generally expressed at very low levels and mainly induced by stimuli such as inflammatory agents, growth factors, etc. , is largely involved in cancer initiation and ...

Chromosome 9: 125,132,824-125,157,982 forward strand. GRCh37:CM000671.1. This gene has 5 transcripts (splice variants) and 1 paralogue. Show transcript table. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?db=core;g=ENSG00000095303;r=9:125132824-125157982;time=1741134649670.67" failed to load.

2016年9月14日 · Enables prostaglandin-endoperoxide synthase activity. Involved in cyclooxygenase pathway. Located in Golgi apparatus. Biomarker of several diseases, including Creutzfeldt-Jakob disease; brain ischemia; female reproductive organ cancer (multiple); glioblastoma; and salivary gland carcinoma.

2010年3月25日 · Prostaglandin-endoperoxide synthase (PTGS; EC 1.14.99.1; fatty acid cyclooxygenase; PGH synthase) is the key enzyme in prostaglandin biosynthesis. The cyclooxygenase activity of the enzyme is inhibited by nonsteroidal antiinflammatory drugs (NSAID) such as aspirin and endomethacin.

Official gene symbol, which is typically a short form of the gene name, according to HGNC. Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl.