Paraoxonase 1 (PON1) also known as Serum paraoxonase and arylesterase 1, A esterase, homocysteine thiolactonase or serum aryldialkylphosphatase 1, is an enzyme that in humans is encoded by the PON1 gene. [5]

2024年12月25日 · PON1 (Paraoxonase 1) is a Protein Coding gene. Diseases associated with PON1 include Microvascular Complications Of Diabetes 5 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7. Among its related pathways …

2020年9月30日 · The PON1 gene codes for the enzyme serum paraoxonase/arylesterase 1 or PON1 that has esterase and paraoxonase activity. The PON1 enzyme is composed of 354 amino acids and is synthesized by the liver.

2018年2月10日 · Human serum paraoxonase-1 (PON1) is a calcium-dependent hydrolytic enzyme that is found in a variety of mammalian species. Abraham Mazur 1 and Norman Aldridge 2 played a pivotal role in the identification and classification of PON1 in …

2016年5月2日 · PON1 is a very important gene to be aware of in your Nutrition Genome Report. By focusing on nutritional ways to improve PON1 activity and avoiding ways that its function is compromised, you can strengthen your genome against …

PON1 (EC 3.1.1.2) hydrolyzes the toxic oxon metabolites of several organophosphorous insecticides, including parathion, diazinon, and chlorpyrifos, as well as nerve agents, such as sarin and soman. PON1 also hydrolyzes aromatic esters, preferably those of acetic acid.

2022年9月1日 · Paraoxonase 1 (PON1) is a 43–45 kDa glycoprotein aryldialkylphosphatase with 354–355 amino acids. PON1 is thought to prevent atherosclerosis, mainly due to its anti-oxidant activity. It also possesses beneficial effects regarding adhesion, inflammation, apoptosis, thrombosis, as well as lipid-modifying actions (Chistiakov et al., 2017).

2014年3月25日 · Paraoxonase 1 (PON1) is a widely studied enzyme based on its protective role against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in vascular disease, as well as its use as biomarker of diseases involving oxidative stress, inflammation and liver diseases.

2024年12月6日 · PON1 is a Ca2+-dependent enzyme that indicates a hydrolytic activity towards a broad spectrum of substrates. The mechanism of hydrolysis catalyzed by this enzyme is poorly understood. It was shown that the active site of PON1 is highly dynamic.

In this study, we investigated the potential relationship between PON1 activity, PON1 genotype, systemic oxidative stress, and both coronary and peripheral artery disease in a large, prospective cohort of patients to more fully interrogate the aforementioned relationships.