PML Gene - GeneCards | PML Protein | PML Antibody
2024年12月25日 · PML (PML Nuclear Body Scaffold) is a Protein Coding gene. Diseases associated with PML include Acute Promyelocytic Leukemia and Rabies. Among its related pathways are PIP3 activates AKT signaling and Transport of …
PML gene - MedlinePlus
The PML gene provides instructions for a protein that acts as a tumor suppressor, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. The PML protein is found in distinct structures in the nucleus of a cell called PML nuclear bodies (PML-NBs).
Acute Promyelocytic Leukemia: A Constellation of Molecular …
Acute promyelocytic leukemia (APL) is a biologically and clinically distinct subtype of acute myeloid leukemia (AML) with unique molecular pathogenesis, clinical manifestations and treatment that is cytogenetically characterized by a balanced translocation t (15;17) (q24;q21) [1, 2, …
Structure, dynamics and functions of promyelocytic leukaemia …
PML is a tumour suppressor protein that typically localizes to and is necessary for the formation of nuclear macromolecular structures called promyelocytic leukaemia nuclear bodies (PML-NBs)....
PML: Regulation and multifaceted function beyond tumor …
2018年1月25日 · Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to PML–RARα and RARα–PML fusion proteins.
Acute promyelocytic leukemia - MedlinePlus
The mutation that causes acute promyelocytic leukemia involves two genes, the PML gene on chromosome 15 and the RARA gene on chromosome 17. A rearrangement of genetic material (translocation) between chromosomes 15 and 17, written as t(15;17), fuses part of the PML gene with part of the RARA gene.
PML (human) | Gene Target - PubChem
2016年9月14日 · The PML gene provides instructions for a protein that acts as a tumor suppressor, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. The PML protein is found in distinct structures in the nucleus of a cell called PML nuclear bodies (PML-NBs).
5371 - Gene ResultPML PML nuclear body scaffold [ (human)]
PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer. Promyelocytic leukemia protein regulates angiogenesis and epithelial-mesenchymal transition to limit metastasis in MDA-MB-231 breast cancer cells.
The Role of PML in Tumor Suppression - Cell Press
2002年1月25日 · The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.
Definition of PML gene - NCI Dictionary of Cancer Terms
A gene that makes a protein that helps control cell growth and cell division. Mutations (changes) in the PML gene can occur when a piece of the chromosome containing the PML gene breaks off and joins with a gene called RARA on another chromosome.
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