The central nervous system (CNS) of terrestrial vertebrates underwent a prominent molecular change when proteolipid protein (PLP) replaced P0 protein as the most abundant protein of CNS myelin. However, PLP did not replace P0 in peripheral nervous system (PNS) myelin.

Here we show that the abundance of PLP but not of other tetraspan myelin proteins is strongly increased in compact peripheral myelin of P0 (null)-mice. To determine the functional relevance of PLP expression in the absence of P0, we generated P0 (null)*Plp (null)-double-mutant mice.

PLP is a 30-kDa integral membrane protein mainly expressed by CNS oligodendrocytes. Minor expression can be observed in PNS myelin, as well as in kidney distal and proximal tubules . PLP is a tetraspan integral membrane protein with cytoplasmic N and C termini.

1997年7月1日 · The intriguing phylogenetic analyses of P0, DM20, and PLP by Yoshida and Colman 1996 demonstrate that PLP/DM20 is present in PNS compact myelin of teleosts and amphibians, providing an evolutionary precedent for PLP in peripheral myelin.

To investigate the possible consequences of a PLP to P 0 shift in PNS myelin, we engineered mice to express PLP instead of P 0 in PNS myelin (PLP-PNS mice). PLP-PNS mice had severe neurological disabilities and died between 3 and 6 months of age.

Steady-state levels of PLP mRNA in SC cultures treated with the cAMP analogue dibutyryl cAMP (dBcAMP) were not increased, whereas dBcAMP increased steady-state levels of mRNA encoding the major myelin protein, P0. We have also shown that expression of PLP, unlike that of P0, is regulated in SC in vitro at a posttranscriptional level.

2014年7月28日 · The central nervous system (CNS) of terrestrial vertebrates underwent a prominent molecular change when proteolipid protein (PLP) replaced P 0 protein as the most abundant protein of CNS myelin. However, PLP did not replace P …

2025年2月8日 · axonal mitochondria, smooth endoplasmic reticulum, and microtubules were characterized in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein, P0.

Concomitant expression of proteolipid protein (PLP) and P0 in remyelinating cerebral lesion (index case 1). (A) The peripheral nerve from case 4 was stained with an antibody to P0 (green) and an...

PLLP is involved in intracellular transport, lipid raft formation, and Notch signaling. PLLP is presumably involved in various disorders, such as cancer, schizophrenia, Alzheimer’s disease, and type 2 diabetes mellitus. PLLP and its homologs were identified as …