PLGA, PLG, or poly(lactic-co-glycolic) acid (CAS: 26780-50-7) is a copolymer which is used in a host of Food and Drug Administration (FDA) approved therapeutic devices, owing to its biodegradability and biocompatibility. [1]

2014年2月28日 · This paper critically reviews the scientific challenge of manufacturing PLGA-based materials with suitable properties and shapes for specific biomedical applications, with special emphasis on bone tissue engineering.

PLGA and related block and speciality copolymers are sold by PolySciTech ® Division of Akina, Inc. under the trade name PolyVivo. Common uses for our formulations include forming "stealth" pegylated microparticles, thermogelation, water-solubilization of drugs and plasticization of polymer mixtures (non-soluble).

2023年3月17日 · Poly (lactic-co-glycolic acid) (PLGA) is a biodegradable functional polymer made from the polymerization of lactic acid (LA) and glycolic acid (GA) and is widely used in pharmaceuticals and medical engineering materials because of its biocompatibility, non-toxicity, and good plasticity.

2024年9月14日 · The incorporation of drugs into PLGA nanoparticles and microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, and improve patient compliance. Overall, PLGA-based DDSs holds great promise for the advancement of the treatment and management of multiple chronic conditions.

2022年8月1日 · Poly (lactic-co-glycolic acid) (PLGA) is FDA-approved synthetic polymer which can be used to formulate NPs that can be targeted to a specific site for the safe and effective delivery of drugs. PLGA-based NPs can be used for a variety of cancer therapies including tumor-targeted drug delivery, gene therapy, hyperthermia, and photodynamic therapy.

2021年6月29日 · Poly (lactide-co-glycolide) (PLGA) is a biodegradable polymer that is used in most long-acting formulations approved by the FDA. PLGA is used to provide sustained release of drug in various long-acting formulations such as microspheres, in situ gel implants, and solid implants. Long-acting formulations offer many advantages compared to ...

2024年4月11日 · Acid-terminated PLGA breaks down faster, making it a go-to for quicker drug release. Ester-terminated versions, on the other hand, degrade more slowly and are better suited when a prolonged delivery is needed.

Lactic Acid/Glycolic Acid Copolymer (PLGA) is a polymer consisting of Lactic and Glycolic acid units (monomers) specially designed to improve ingredient delivery systems, especially microspheres containing actives.

聚乳酸-羟基乙酸共聚物（poly(lactic-co-glycolic acid)，PLGA）由两种单体——乳酸和羟基乙酸随机聚合而成，是一种可降解的功能高分子有机化合物，具有良好的生物相容性、无毒、良好的成囊和成膜的性能，被广泛应用于制药、医用工程材料和现代化工业领域。