PIM1 - Wikipedia
Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus …
PIM1 Gene - GeneCards | PIM1 Protein | PIM1 Antibody
2024年12月25日 · PIM1 (Pim-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PIM1 include Myeloma, Multiple and Myeloproliferative …
Why target PIM1 for cancer diagnosis and treatment? - PMC
The highly conserved proto-oncogenic protein PIM1 is an unusual serine or threonine kinase, in part because it is constitutively active. Overexpression of PIM1 experimentally leads to tumor …
PIM1 kinase and its diverse substrate in solid tumors - PMC
PIM1 kinase is often overexpressed in solid and hematopoietic malignancies, promoting cell survival, proliferation, migration, and senescence by activating key genes. In vitro and in vivo …
PIM1 kinase as a promise of targeted therapy in prostate cancer …
As PIM1 has great potential to induce cancer stem cell properties to accelerate prostate cancer progression, targeting PIM1 in cancer stem cells using selective inhibitors may provide a new …
PIM1 kinase regulates cell death, tumor growth and ... - Nature
2016年10月24日 · In triple-negative breast cancer, the kinase PIM1, which is highly expressed, functions through the transcription factor c-MYC to promote tumor cell survival and growth.
PIM1 kinase and its diverse substrate in solid tumors
2024年11月1日 · PIM1 kinase is often overexpressed in solid and hematopoietic malignancies, promoting cell survival, proliferation, migration, and senescence by activating key genes. In …
Targeting cytokine- and therapy-induced PIM1 activation in …
2020年5月7日 · Proviral integration site for Moloney-murine leukemia 1 (PIM1) is a known JAK-STAT target gene that recently emerged as a therapeutic target for the treatment of T-ALL and …
UniProt
Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and …
Biological and Clinical Significance of PIM1 Genetic Alterations in ...
2021年11月5日 · Background: PIM1 is a somatic hypermutation gene in diffuse large B-cell lymphoma (DLBCL) and its inhibitors exhibit a great value in application in multiple types of …
Pim-1, Beyond an Oncogene, in Acute Myeloid Leukemia
2015年12月3日 · It is reported that Pim-1 plays a role in solid tumor, leukemia and polycythemia vera, et al. Pim-3, as a newly cloned oncogene has discovered to functioning in hepatic …
PIM1 kinase regulates cell death, tumor growth and …
We identify PIM1 as a malignant cell-selective target in TNBC, illustrating relationships with MYC activation, regulation of anti-apoptotic BCL2 and MCL1, established TNBC oncogenic proteins …
PIM1 controls GBP1 activity to limit self-damage and to guard
Infection causes the production of the inflammatory cytokine interferon-γ (IFN-γ), which triggers the expression of hundreds of IFN-stimulated-genes, including the kinase PIM1 and GBP1, a …
Pim1 promotes human prostate cancer cell tumorigenicity and …
2010年6月1日 · Our results suggest an in vivo role of Pim1 in promoting prostate tumorigenesis although it displayed distinct oncogenic activities depending on the disease stage of the cell …
Pim1 is Critical in T-cell-independent B-cell Response and MAPK ...
2024年12月1日 · Pim1 deficiency reduces BCR-induced cell proliferation and cell cycle progression. Pim1 deficiency impairs BCR-induced MAPK activation. The Pim family consists …
Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against HER2 …
The proviral integration site for moloney murine leukemia virus 1 (Pim1) is a serine/threonine kinase and able to promote cell proliferation, survival and drug resistance. Overexpression of …
MALT lymphoma and extranodal diffuse large B-cell lymphoma …
2006年12月29日 · In DLBCL somatic hypermutation aberrantly targets the 5′ sequences of several proto-oncogenes relevant to lymphomagenesis, including PIM1, PAX5, RhoH/TTF, …
PIM1 alleviated liver oxidative stress and NAFLD by
2024年7月15日 · PIM1 targets the NRF2/HO-1/NQO1 signaling pathway to resist oxidative stressors and apoptosis. PIM1 improves hepatic function, inflammation, and lipogenesis to …
COMPOSITIONS AND METHODS FOR SERIAL TARGET DETECTION
Disclosed herein, inter alia, are methods and compositions useful for serially detecting multiple biological targets.
Aberrant somatic hypermutation in tumor cells of nodular …
2006年8月1日 · To assess whether the SHM process functions aberrantly in HL, we investigated tumor cells microdissected from frozen lymph node samples of NLPHL and cHL for the …
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