It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in …

Dec 25, 2024 · PIAS1 (Protein Inhibitor Of Activated STAT 1) is a Protein Coding gene. Diseases associated with PIAS1 include Nephronophthisis and Germ Cell Cancer. Among its related …

PIAS1包含了一个内在的激活结构域,对雄激素受体的转录有双向的功能,使得低水平表达能抑制转录,高水平的表达能诱导转录。 由于PIAS1中该结构域的存在,PIAS1与其他成员相比在调节雄激 …

Feb 28, 2020 · PIAS1 (protein inhibitor of activated STAT1)蛋白是一种可以抑制信号转导与转录激活子1 (STAT1)的特异性抑制蛋白，同时具有SUMO连接酶E3的活性，参与多种转录因子的活 …

该基因编码激活 STAT (PIAS) 蛋白抑制剂家族的成员。 PIAS 蛋白作为 SUMO E3 连接酶发挥作用，并通过介导靶蛋白的 SUMO 化在许多细胞过程中发挥重要作用。 这种蛋白质作为众多细胞 …

Mar 8, 2025 · Title: SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer. Crosstalk between SUMOylation …

Feb 11, 2020 · Increasing evidence shows that PIAS1 is overexpressed in various human malignancies, including prostate and lung cancers. Here we used quantitative SUMO …

May 1, 2017 · PIAS1（protein inhibitor of activated signal transducer and activators of transcription 1）蛋白是一种可以抑制信号转导与转录激活子1（signal transducer and …

Apr 15, 2024 · Protein inhibitor of activated signal transducer and activators of transcription 1 (PIAS1) is a small ubiquitin-like modifier (SUMO) E3 ligase, which plays a crucial role in …

Aug 1, 2005 · PIAS1 has specific effects on cytokine-mediated signalling by selectively regulating a subset of interferon- or tumour-necrosis-factor-responsive genes. PIAS1 is important in …

PIAS1 (protein inhibitor of activated signal transducer and activators of transcription 1)蛋白是一种可以抑制信号转导与转录激活子1 (signal transducer and activators of transcription...

Nov 29, 2012 · Protein inhibitor of activated signal transducer and activator of transcription-1 (PIAS1) is known to function as small ubiquitin-like modifier (SUMO) E3 ligase as well as …

Aug 15, 2004 · Using PIAS1-deficient cells, we show that PIAS1 selectively regulates a subset of IFN-γ- or IFN-β-inducible genes by interfering with the recruitment of STAT1 to the gene …

Mar 24, 2024 · Most frequently reported PIAS family members in cancer development are PIAS1 and PIAS3. SUMOylation as post-translational modifier regulates several cellular machineries. …

Feb 24, 2014 · We report here that the PIAS1 SUMO ligase is involved in the progression of breast tumorigenesis. Elevated PIAS1 expression was observed in breast tumor samples. …

Jun 1, 2007 · Protein inhibitor of activated STAT1 (PIAS1), a transcriptional regulator that possesses small ubiquitin-related modifier (SUMO) E3 ligase activity, inhibits immune …

Aug 16, 2023 · Our study proved that PIAS1 suppressed vascular endothelial injury and atherosclerotic plaque formation in mouse models of diabetes via the RUNX3/TSP-1 axis. …

The discovery of PIAS3 was first published in 1997. The discovery was made while the JAK-STAT pathway was being studied. [1] The discovery of other PIAS proteins, including PIAS1, …

Feb 11, 2020 · The protein inhibitor of activated STAT1 (PIAS1) is an E3 SUMO ligase that plays important roles in various cellular pathways. Increasing evidence shows that PIAS1 is …

Oct 22, 2010 · We report here that the SUMO E3 ligase PIAS1 restricts the differentiation of natural T reg cells by maintaining a repressive chromatin state of the Foxp3 promoter. PIAS1 …