It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [7]

2024年12月25日 · PIAS1 (Protein Inhibitor Of Activated STAT 1) is a Protein Coding gene. Diseases associated with PIAS1 include Nephronophthisis and Germ Cell Cancer. Among its related pathways are Transport of the SLBP independent Mature mRNA and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

2025年3月8日 · Title: SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer. Crosstalk between SUMOylation and ubiquitylation controls DNA end resection …

2020年2月11日 · Here we used quantitative SUMO proteomics to identify potential substrates of PIAS1 in a system-wide manner. We identified 983 SUMO sites on 544 proteins, of which 62 proteins were assigned as...

PIAS1 was found to interact with C/EBPβ through the SAP (scaffold attachment factor A/B/acinus/PIAS) domain and SUMOylate it, leading to increased ubiquitination and degradation of C/EBPβ. C/EBPβ became more stable when PIAS1 was silenced by RNA interference (RNAi).

Protein inhibitors of activated STATs (PIAS) are proteins for cytokine signaling that activate activator-mediated gene transcription. These proteins, as versatile cellular regulators, have been described as regulators of approximately 60 proteins.

2005年8月1日 · PIAS1 has specific effects on cytokine-mediated signalling by selectively regulating a subset of interferon- or tumour-necrosis-factor-responsive genes. PIAS1 is important in innate immunity....

2004年8月15日 · Using PIAS1-deficient cells, we show that PIAS1 selectively regulates a subset of IFN-γ- or IFN-β-inducible genes by interfering with the recruitment of STAT1 to the gene promoter.

2024年4月15日 · Protein inhibitor of activated signal transducer and activators of transcription 1 (PIAS1) is a small ubiquitin-like modifier (SUMO) E3 ligase, which plays a crucial role in variety of biological processes both in vitro and in vivo, such as inflammation [9].

The discovery of PIAS3 was first published in 1997. The discovery was made while the JAK-STAT pathway was being studied. [1] The discovery of other PIAS proteins, including PIAS1, PIASxα, PIASxβ, and PIASy, was published the following year. [2] The interaction between STATs and PIASs was characterized by the yeast two-hybrid assay. [1] [2] PIAS proteins were named based on their ability to ...