Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication. [2][3][4] Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open. [2][5] In babies it is used in those wit...

Prostaglandin E2 (PGE2), which involves diverse physiological processes via E-type prostanoid (EP) receptor family, favors the regeneration of various organ systems following injury for its capabilities such as activation of endogenous stem cells, immune regulation, and angiogenesis.

2023年6月5日 · Prostaglandin E2 (PGE2), also known by the name dinoprostone, is a naturally occurring compound involved in promoting labor, though it is also present in the inflammatory pathway. Prostaglandin E2 is FDA approved for cervical ripening for the induction of labor in patients for which there is a medical indication for induction.

Prostaglandin E 2 (PGE 2), an essential homeostatic factor, is also a key mediator of immunopathology in chronic infections and cancer. The impact of PGE 2 reflects the balance between its COX2-regulated synthesis and 15-PGDH-driven degradation, and the pattern of expression of PGE 2 receptors.

2020年3月15日 · Prostaglandin E2 (PGE2) is a principal mediator of inflammation in diseases such as rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors reduce PGE2 production to diminish the inflammation seen in these disease …

Prostaglandin E 2 (PGE 2) is a bioactive lipid that elicits a wide range of biological effects associated with inflammation and cancer. PGE 2 exerts diverse effects on cell proliferation, apoptosis, angiogenesis, inflammation and immune surveillance.

2024年4月24日 · Here we demonstrate that tumour-derived prostaglandin E2 (PGE 2) restricts the proliferative expansion and effector differentiation of TCF1 + CD8 + T cells within tumours, which promotes cancer...

2024年11月1日 · While prostaglandin E 2 (PGE 2) is produced in human tumor microenvironment (TME), its role therein remains poorly understood. Here, we examine this issue by comparative single-cell RNA...

Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1-EP4) to elicit its diverse actions including pyrexia, pain …

2016年3月18日 · We observed that prostaglandin E 2 (PGE 2), through its receptor EP4, is down-regulated in human systemic inflammatory disease. Mice with reduced PGE 2 synthesis develop systemic inflammation, associated with translocation of gut bacteria, which can be prevented by treatment with EP4 agonists.