Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP 1), as well as CRTH2 (DP 2). [1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, …

2018年9月29日 · The DP2 receptor pathway is a novel and important therapeutic target for asthma, because increased PGD2 production induces significant inflammatory cell chemotaxis …

Prostaglandin D2 (PGD2) is a major inflammatory mediator produced by mast cells and Th2 cells. PGD2 and its metabolites have been considered as selective markers of mast cell activation in …

PGD 2 can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD 2 provide opportunities for …

The prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D 2. [1][2] Also known as PTGDR or DP receptors, they are …

2016年7月16日 · Prostaglandin D2 (PGD2) is the predominant prostaglandin product released by mast cells. It is found prevalently in the central nervous system and peripheral tissues, where it …

It is a conjugate acid of a prostaglandin D2 (1-). The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by …

Increased production of Prostaglandin D 2 (PGD 2) is linked to development and progression of asthma and allergy. PGD 2 is rapidly degraded to its metabolites, which initiate type 2 innate …

2017年11月17日 · Prostaglandin (PG) D2 is a major PG produced in the central nervous system and is involved in the regulation of sleep and pain responses through DP receptors. It is also …

Prostaglandin (PG) D 2 and PGE 2 are positional isomers; however, they sometimes exhibit opposite physiological functions, such as in cancer development. Because DP receptors are …