Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP 1), as well as CRTH2 (DP 2). [1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD 2 are found only in the brain and in mast cells.

2018年9月29日 · The DP2 receptor pathway is a novel and important therapeutic target for asthma, because increased PGD2 production induces significant inflammatory cell chemotaxis and degranulation via its interaction with the DP2 receptor.

Prostaglandin D2 (PGD2) is a major inflammatory mediator produced by mast cells and Th2 cells. PGD2 and its metabolites have been considered as selective markers of mast cell activation in vivo.

PGD 2 can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD 2 provide opportunities for development of novel therapeutic approaches for resistant infections and …

The prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D 2. [1][2] Also known as PTGDR or DP receptors, they are important for various functions of the nervous system and inflammation. They include the following proteins:

2016年7月16日 · Prostaglandin D2 (PGD2) is the predominant prostaglandin product released by mast cells. It is found prevalently in the central nervous system and peripheral tissues, where it performs both inflammatory and normal processes. In the brain, PGD2 helps to regulate sleep and pain perception.

It is a conjugate acid of a prostaglandin D2 (1-). The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.

Increased production of Prostaglandin D 2 (PGD 2) is linked to development and progression of asthma and allergy. PGD 2 is rapidly degraded to its metabolites, which initiate type 2 innate lymphoid cells (ILC2) migration and IL-5/IL-13 cytokine secretion in a PGD 2 receptor 2 (DP 2)-dependent manner.

2017年11月17日 · Prostaglandin (PG) D2 is a major PG produced in the central nervous system and is involved in the regulation of sleep and pain responses through DP receptors. It is also actively produced by mast cells, basophils, and Th2 cells, acting as an allergic mediator through DP and CRTH2 receptors.

Prostaglandin (PG) D 2 and PGE 2 are positional isomers; however, they sometimes exhibit opposite physiological functions, such as in cancer development. Because DP receptors are considered to be a duplicated copy of EP2 receptors, PGD 2 and PGE 2 cross-react with both receptors. These prostanoids may act as biased agonists for each receptor.