Dec 25, 2024 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming. Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in …

Apr 6, 2022 · PDK1 (3-phosphoinositide-dependent kinase 1) is a serine/threonine-protein kinase that plays a central role in regulating cell growth, survival, and proliferation. Knocking out …

An increasing amount of evidence hints at 3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) as an intriguing and underexplored target for cancer therapy. Several reports show …

PDK1 is a transducer of PI3K signaling and activates multiple downstream effectors, thereby representing an essential hub coordinating signals coming from extracellular cues to the …

Nov 7, 2023 · PDKs (PDK1–4) are important regulator enzymes of mitochondrial aerobic metabolism, which can inhibit the activity of the pyruvate dehydrogenase (PDH) complex by …

PDK1 is a 63 KDa Ser/Thr kinase with carboxyl terminal PH domain that binds with high affinity to PIP3-containing regions of plasma membrane and phosphorylates the colocalised AKT at its …

Apr 1, 2004 · Here, we review recent biochemical, genetic and structural studies on the 3-phosphoinositide-dependent protein kinase-1 (PDK1), which phosphorylates and activates the …

Feb 1, 2018 · This review analyzes the up-to-date knowledge supporting PDK1 involvement in altered signaling in cancer, what cancer types and subtypes would benefit from a PDK1 …