PDPK1 is a master kinase, which is crucial for the activation of AKT /PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signaling pathways …

2024年12月25日 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …

2022年4月6日 · PDK1 (3-phosphoinositide-dependent kinase 1) is a serine/threonine-protein kinase that plays a central role in regulating cell growth, survival, and proliferation. Knocking …

Nucleus-located PDK1 regulates growth, invasion and migration of breast cancer cells. These findings highlight the potential use of PGK1 mRNA level, PGK1 promoter hypomethylation, …

PDK1, as an important direct target for metabolism, inhibits pyruvate flux to mitochondrial respiration. A rescue of PDK1 expression in Wnt-inhibited cancer cells rescues glycolysis as …

PDK-1 是 PI3K 通路中的关键节点，通过磷酸化和随后激活许多其他 AGC 激酶家族成员（如蛋白激酶 B），在胰岛素和生长因子信号传导中发挥关键作用。 PDK-1 负责调节细胞增殖和迁 …

In humans, there have been four isozymes of Pyruvate Dehydrogenase Kinase that have been shown to phosphorylate these three sites: PDK1, PDK2, PDK3, and PDK4. PDK1 is the only …

2018年2月1日 · This review analyzes the up-to-date knowledge supporting PDK1 involvement in altered signaling in cancer, what cancer types and subtypes would benefit from a PDK1 …

2022年3月1日 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML)....

An increasing amount of evidence hints at 3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) as an intriguing and underexplored target for cancer therapy. Several reports show …