2024年12月25日 · PDGFRA (Platelet Derived Growth Factor Receptor Alpha) is a Protein Coding gene. Diseases associated with PDGFRA include Gist-Plus Syndrome and Gastrointestinal Stromal Tumor. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

The protein is encoded in the human by the PDGFRA gene. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation .

血小板衍生生长因子(pdgf)结合两种密切相关的受体酪氨酸激酶，pdgf受体α和β，这两种受体由pdgfra和pdgfrb基因编码。pdgf受体的异常激活发生在与嗜酸性粒细胞增多症相关的髓系恶性肿瘤中，这是由于染色体改变产生…

pdgfra在少突胶质祖细胞和间皮细胞中表达，可高亲和力结合3个配体异构体pdgf-aa、pdgf-bb和pdgf-ab。 PDGFRA在调节肾小球系膜细胞的增殖、趋化作用和迁移上起重要作用。

PDGFRA/Pdgfra gene is regulated by at least seven first exons in human and mouse. our findings support a pathogenetic relationship between telocyte hyperplasia and both inflammatory fibroid polyp and PDGFRA-mutant gastrointestinal stromal tumour (GIST).

The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this gene and related health conditions.

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in gastrointestinal stromal tumors (GISTs), inflammatory fibroid polyps and gliomas, and PDGFRB mutations drive myofibroma development. In addition, chromosomal rearrangement of ...

2023年12月2日 · UMAP distinguished antral Pdgfra Hi (AntHi) and Pdgfra Lo (AntLo) cells and a substantial (44% of Pdgfra + cells) third pool, AntInt, with intermediate Pdgfra and Cd34 levels and a...

用于研究大脑中动脉梗塞。皮肤慢性溃疡生物标志物；高血压;羊水过少;肺纤维化;和坐骨神经病。该基因的人类直系同源物与血液癌症有关（多个）；嗜酸性粒细胞增多症;和胰腺癌。与人 pdgfra（血小板衍生生长因子受体 α）同源。

Myeloid And Lymphoid Neoplasms With Eosinophilia And Rearrangement Of Pdgfra, Pdgfrb, Or Fgfr1, Or With Pcm1-Jak2